2-Methyl-5-pyrimidinamine
- Product Name
- 2-Methyl-5-pyrimidinamine
- CAS No.
- 39889-94-6
- Chemical Name
- 2-Methyl-5-pyrimidinamine
- Synonyms
- NSC 165371;2-Methyl-5-pyrimidinamin;2-methyl-5-pyrimidinamine;5-AMino-2-MethylpyriMidin;2-methylpyrimidin-5-amine;2-METHYL-5-AMINOPYRIMIDINE;2-methylpyrimidine-5-amine;5-Amino-2-methylpyrimidine;5-AMino-2-Methyl-pyriMidin;5-Pyrimidinamine, 2-methyl-
- CBNumber
- CB9855005
- Molecular Formula
- C5H7N3
- Formula Weight
- 109.13
- MOL File
- 39889-94-6.mol
2-Methyl-5-pyrimidinamine Property
- Melting point:
- 158-161°C
- Boiling point:
- 140°C (2 Torr)
- Density
- 1.155
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 3.17±0.22(Predicted)
- Appearance
- Light yellow to brown Solid
- CAS DataBase Reference
- 39889-94-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M338005
- Product name
- 2-Methylpyrimidin-5-amine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 072502
- Product name
- 5-Amino-2-methylpyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA44296
- Product name
- 5-Amino-2-methylpyrimidine
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FA44296
- Product name
- 5-Amino-2-methylpyrimidine
- Packaging
- 2g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- Q097
- Product name
- 5-Amino-2-methylpyrimidine
- Packaging
- 5g
- Price
- $321
- Updated
- 2021/12/16
2-Methyl-5-pyrimidinamine Chemical Properties,Usage,Production
Synthesis
39906-04-2
39889-94-6
The general procedure for the synthesis of 5-amino-2-methylpyrimidine from 2-methyl-4,6-dichloro-5-aminopyrimidine is as follows: Example 77: Preparation of (1S,2R)-2-(4-(diisobutylamino)-3-(3-(2-methylpyrimidin-5-yl)ureido)phenyl)cyclopropanecarboxylic acid 77A. Step 77A: Synthesis of 5-amino-2-methylpyrimidine 1. 4,6-dichloro-2-methylpyrimidin-5-amine (2 g, 11.23 mmol) was dissolved in ether (93 ml). 2. aqueous solution of sodium hydroxide (7.37 g, 184 mmol) (22.05 ml) and 10% palladium-carbon catalyst (0.161 g, 1.517 mmol) were added to the above solution. 3. The reaction mixture was subjected to a hydrogen atmosphere at 50 psi and the reaction was shaken on a Par oscillator for 22 hours at room temperature. 4. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with dichloromethane (DCM). 5. The solvent in the filtrate was evaporated to give a yellow residue. 6. The residue was resuspended in a solvent mixture of DCM and water. 7. The pH of the aqueous layer was adjusted to about 6 with 4N HCl, followed by extraction of the aqueous layer with DCM (3 times). 8. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated to give a yellow residue. 9. As the aqueous phase still contained product, the aqueous phase was evaporated to give a yellow solid. 10. The solid was dissolved in a solvent mixture of methanol (MeOH) and DCM and filtered to remove the insoluble salt. 11. The filtrate was evaporated to give a yellow residue. 12. The products from the extracted and aqueous layers were purified separately by fast chromatography and the purified products were combined to give 77A (off-white solid, 0.968 g, 8.87 mmol, yield 79%). Product characterization: 1H NMR (400 MHz, chloroform-d) δ 8.14 (s, 2H), 3.60 (br.s., 2H), 2.61 (s, 3H).
References
[1] Patent: WO2014/150677, 2014, A1. Location in patent: Page/Page column 121; 122
[2] Helvetica Chimica Acta, 1958, vol. 41, p. 1806,1812
2-Methyl-5-pyrimidinamine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methyl-5-pyrimidinamine Suppliers
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- Country
- India
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View Lastest Price from 2-Methyl-5-pyrimidinamine manufacturers
- Product
- 2-Methyl-5-pyrimidinamine 39889-94-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
- Product
- 2-Methyl-5-pyrimidinamine 39889-94-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 2-Methyl-5-pyrimidinamine 39889-94-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10