Mephenoxalone
- Product Name
- Mephenoxalone
- CAS No.
- 70-07-5
- Chemical Name
- Mephenoxalone
- Synonyms
- Xerene;Dorsiflex;Metoxadone;Mefenonone;Methoxydone;mephenoxalone;TAB Lenetranat;Lenetran Lenetran;5-(o-MethoxyphenoxyMethyl)-2-oxazolidinone;5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone
- CBNumber
- CB9887684
- Molecular Formula
- C11H13NO4
- Formula Weight
- 223.23
- MOL File
- 70-07-5.mol
Mephenoxalone Property
- Melting point:
- 143-145°
- Boiling point:
- 364.51°C (rough estimate)
- Density
- 1.2446 (rough estimate)
- refractive index
- 1.4960 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.24±0.40(Predicted)
- color
- White to Off-White
- NIST Chemistry Reference
- 2-Oxazolidinone, 5-[(o-methoxyphenoxy)methyl]-(70-07-5)
Safety
- Toxicity
- LD50 orally in rats: 3820 ±17 mg/kg (Goldenthal)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M224900
- Product name
- Mephenoxalone
- Packaging
- 25mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- API0008047
- Product name
- MEPHENOXALONE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $510
- Updated
- 2021/12/16
- Product number
- API0008047
- Product name
- MEPHENOXALONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1280
- Updated
- 2021/12/16
- Product number
- CM128782
- Product name
- 5-((2-methoxyphenoxy)methyl)oxazolidin-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $333
- Updated
- 2021/12/16
Mephenoxalone Chemical Properties,Usage,Production
Originator
Trepidone,Lederle, ,1961
Uses
Muscle relaxant, also used as a mild tranquilizer.
Uses
Mephenoxalone is used as a muscle relaxant, also as a mild tranquilizer.
Uses
Prostaglandin F2á ethyl amide Lumigan (0.03% bimatoprost ophthalmic solution)
Definition
ChEBI: Mephenoxalone is a member of methoxybenzenes.
Manufacturing Process
A mixture of 24.1 g (0.10 mol) of 3-o-methoxyphenoxy-2-hydroxy-1-propyl carbamate and 6.0 g (0.10 mol) of urea was heated rapidly to the temperature range of 180°C to 200°C, and maintained there for five hours. The reaction melt was poured into 50% ethyl alcohol, from which the product crystallized as a white solid. The crude yield was 18.3 g (82%); melting point 131.5% to 137°C. Crystallization from water and 95% alcohol gave 9.0 g (40.3 %) of pure 5-o-methoxyphenoxymethyl-2-oxazolidone; melting point 141°C to 143°C. This melting point was not depressed when the material was mixed with an authentic sample. In additional runs acetone was used instead of ethyl alcohol with equivalent results.
It was found that when the heating time was reduced to three hours and a reaction temperature of 190°C to 200°C was maintained, equivalent yields (40 to 50%) were obtained, but that the yields were appreciably lowered when the heating time was further reduced to two hours. It was also found that when the temperature was lowered to the range of 170°C to 180°C the yield was significantly lowered.
When the material was isolated by extraction with chloroform and distillation,
the yield of pure material was 58.5%.
brand name
MI. Lenetran (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
Mephenoxalone Preparation Products And Raw materials
Raw materials
Preparation Products
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