pyridoxal Property

Melting point:

165 °C

Boiling point:

412.8±40.0 °C(Predicted)

Density 

1.360±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

pKa 4.20 (H2O t = 25 I = 0.1)(Approximate)

form 

Solid

color 

White to off-white

EPA Substance Registry System

4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl- (66-72-8)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

pyridoxal Chemical Properties,Usage,Production

Definition

ChEBI: A pyridinecarbaldehyde that is pyridine-5-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 4 respectively.

Enzyme inhibitor

This photosensitive aldehyde form of vitamin B6 (FW = 167.16 g/mol), systematically referred to as 3-hydroxy-5-(hydroxymethyl)-2-methyl-4- pyridinecarboxaldehyde, is the immediate precursor to the coenzyme pyridoxal 5’-phosphate (PLP) and is often a weaker competitive inhibitor of PLP binding to PLP-dependent enzymes). Pyridoxal is soluble in water (1 g/2 mL) and sensitive to heat, particularly at alkaline pH. The pKa values are 4.23 (phenol OH), 8.70 (pyridinium NH+), and 13.0. Pyridoxal has a lmax value of 252 nm at pH 7.0 (e = 8200 M–1cm–1). It is typically supplied as the hydrochloride. Target(s): O-acetylhomoserine aminocarboxypropyltransferase, or O-acetylhomoserine (thiol)-lyase; alanine racemase; aldehyde dehydrogenase; arginine decarboxylase; cystathionine b-lyase, or cystine lyase; cysteine synthase; dextransucrase; b-fructofuranosidase, or invertase; glutamate dehydrogenase; hemoglobin S polymerization; hydroxyacyl-glutathione hydrolase, or glyoxalase II; kynurenine 3- monooxygenase; lactoylglutathione lyase, or glyoxalase I; NMN nucleosidase; phosphopantothenoylcysteine decarboxylase; porphobilinogen synthase, or d-aminolevulinate dehydratase; pyridoxal kinase; pyridoxal phosphatase, weakly inhibited; starch phosphorylase; thiamin phosphatase; tyrosinase; and xanthine dehydrogenase.