ChemicalBook > CAS DataBase List > (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Product Name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
CAS No.: 477600-70-7
Chemical Name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Synonyms: Tofacitinib int;Tofacitinib Impurity 16;Tofacitinib intermediate 2;(3R,4R)-1-Benzyl-N,4-diMe...;7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol;(Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine;(3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE;(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine;CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE;(3R,4R)-N,4-DiMethyl-1-benzyl-3-piperidinaMine
CBNumber: CB9947702
Molecular Formula: C14H22N2
Formula Weight: 218.34
MOL File: 477600-70-7.mol

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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Property

Boiling point:: 302.6±35.0 °C(Predicted)
Density: 1.00±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 10.26±0.40(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C14H22N2/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3/t12-,14+/m1/s1
InChIKey: NVKDDQBZODSEIN-OCCSQVGLSA-N
SMILES: N1(CC2=CC=CC=C2)CC[C@@H](C)[C@@H](NC)C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D464895
Product name: (3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine
Packaging: 25g
Price: $1485
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-16
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Purity: 95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 073486
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Purity: 95+%
Packaging: 250mg
Price: $247
Updated: 2021/12/16

AK Scientific

Product number: J50913
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Packaging: 1g
Price: $249
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-16
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Purity: 95%
Packaging: 5G
Price: $325
Updated: 2021/12/16

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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Chemical Properties,Usage,Production

Uses

(3R,?4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine (D464895) is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

Synthesis

1615709-89-1

477600-70-7

The general procedure for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-(methylamino)pyridin-1-ium bromide as a raw material for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidines was as follows: 1-benzyl-3-methylamino-4-methyl-pyridinium bromide (10 g, 34.1 mmol) was placed in a 250 ml reaction flask, ethanol (100 g) was added, and a temperature of below 30°C and stirring was started. Sodium borohydride (3.87 g, 102.3 mmol) was added slowly and after addition, the reaction was continued with stirring for 16 h. The reaction was monitored by HPLC until the content of raw material was below 1%. Subsequently, 2M HCl solution was slowly added dropwise to the reaction system until no bubbles were generated. The reaction solution was concentrated to one third of the original volume under reduced pressure. It was extracted twice with dichloromethane, the organic phases were combined and concentrated under reduced pressure to remove the solvent. To the resulting crude product, ethanol (40 g) was added and 2M hydrochloric acid ethanol solution (20 ml) was slowly added dropwise at a temperature below 30 °C. A solid precipitated. After dropwise addition, stirring was continued for 1 h. Subsequently, filtration was carried out and the filter cake was dried under reduced pressure. The final white solid product (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidine (6.9 g, 23.8 mmol) was obtained in 70% yield.

References

[1] Patent: CN108610279, 2018, A. Location in patent: Paragraph 0014; 0016

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine manufacturers

Henan Fengda Chemical Co., Ltd

Product: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Hangzhou ICH Biofarm Co., Ltd

Product: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200
Release date: 2023-07-17

Shanghai CRM New Material Technology Co., LTD

Product: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-21

477600-70-7, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amineRelated Search:

Chloropretadalafil cis-Octahydroisoindole Tetrahydro-5-oxo-2- furancarboxyli (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE cis-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate cis-3-azabicyclo[3,3,0]oct-2-ene (1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Tofacitinib Impurity 6 (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanaMide 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 3-bis(4-Methylbenzoyloxy)succinate) 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine

(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine hydrochloride

3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, (3R,4R)-

(3R,4R)-(1-benzyl-4-Methylpiperidin-3-yl)MethylaMine

(3R,4R)-1-Benzyl-N,4-diMe...

(3R,4R)-1-Benzyl-N-Methyl-4-Methylpiperidin-3-aMine

(3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE

(3R,4R)-N,4-DiMethyl-1-benzyl-3-piperidinaMine

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE

(3R,4R)-1-Benzyl-N-methyl-4-methylpiperdin-3-amine

Tofacitinib int-1 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Tofacitinib intermediate 2

Tofacitinib Impurity 16

Cis-1-benzyl-4-methyl-3-methylamino-piperidine

Tofacitinib int

(3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine ISO 9001：2015 REACH

7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol

477600-70-7