ChemicalBook > CAS DataBase List > (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Product Name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
CAS No.
477600-70-7
Chemical Name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Synonyms
Tofacitinib int;Tofacitinib Impurity 16;Tofacitinib intermediate 2;(3R,4R)-1-Benzyl-N,4-diMe...;7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol;(Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine;(3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE;(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine;CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE;(3R,4R)-N,4-DiMethyl-1-benzyl-3-piperidinaMine
CBNumber
CB9947702
Molecular Formula
C14H22N2
Formula Weight
218.34
MOL File
477600-70-7.mol
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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Property

Boiling point:
302.6±35.0 °C(Predicted)
Density 
1.00±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
10.26±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C14H22N2/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3/t12-,14+/m1/s1
InChIKey
NVKDDQBZODSEIN-OCCSQVGLSA-N
SMILES
N1(CC2=CC=CC=C2)CC[C@@H](C)[C@@H](NC)C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D464895
Product name
(3R,​4R)​-N,​4-​Dimethyl-​1-​benzyl​-3-​piperidinamine
Packaging
25g
Price
$1485
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0003359
Product name
(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE
Purity
95.00%
Packaging
1G
Price
$2157.54
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0003359
Product name
(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE
Purity
95.00%
Packaging
5G
Price
$5031.18
Updated
2021/12/16
Matrix Scientific
Product number
073486
Product name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Purity
95+%
Packaging
250mg
Price
$247
Updated
2021/12/16
AK Scientific
Product number
J50913
Product name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Packaging
1g
Price
$249
Updated
2021/12/16
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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Chemical Properties,Usage,Production

Uses

(3R,?4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine (D464895) is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

Synthesis

1615709-89-1

477600-70-7

The general procedure for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-(methylamino)pyridin-1-ium bromide as a raw material for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidines was as follows: 1-benzyl-3-methylamino-4-methyl-pyridinium bromide (10 g, 34.1 mmol) was placed in a 250 ml reaction flask, ethanol (100 g) was added, and a temperature of below 30°C and stirring was started. Sodium borohydride (3.87 g, 102.3 mmol) was added slowly and after addition, the reaction was continued with stirring for 16 h. The reaction was monitored by HPLC until the content of raw material was below 1%. Subsequently, 2M HCl solution was slowly added dropwise to the reaction system until no bubbles were generated. The reaction solution was concentrated to one third of the original volume under reduced pressure. It was extracted twice with dichloromethane, the organic phases were combined and concentrated under reduced pressure to remove the solvent. To the resulting crude product, ethanol (40 g) was added and 2M hydrochloric acid ethanol solution (20 ml) was slowly added dropwise at a temperature below 30 °C. A solid precipitated. After dropwise addition, stirring was continued for 1 h. Subsequently, filtration was carried out and the filter cake was dried under reduced pressure. The final white solid product (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidine (6.9 g, 23.8 mmol) was obtained in 70% yield.

References

[1] Patent: CN108610279, 2018, A. Location in patent: Paragraph 0014; 0016

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Suppliers

China 201 Germany 1 India 5 United States 16 Global 223
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
--
Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
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View Lastest Price from (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine manufacturers

Henan Fengda Chemical Co., Ltd
Product
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Hangzhou ICH Biofarm Co., Ltd
Product
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200
Release date
2023-07-17
Shanghai CRM New Material Technology Co., LTD
Product
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 477600-70-7
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
10t
Release date
2022-09-21

477600-70-7, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amineRelated Search:

Chloropretadalafil cis-Octahydroisoindole Tetrahydro-5-oxo-2- furancarboxyli (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE cis-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate cis-3-azabicyclo[3,3,0]oct-2-ene (1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Tofacitinib Impurity 6 (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanaMide 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 3-bis(4-Methylbenzoyloxy)succinate) 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

  • (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
  • (Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine
  • (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine hydrochloride
  • 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, (3R,4R)-
  • (3R,4R)-(1-benzyl-4-Methylpiperidin-3-yl)MethylaMine
  • (3R,4R)-1-Benzyl-N,4-diMe...
  • (3R,4R)-1-Benzyl-N-Methyl-4-Methylpiperidin-3-aMine
  • (3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE
  • (3R,4R)-N,4-DiMethyl-1-benzyl-3-piperidinaMine
  • CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE
  • (3R,4R)-1-Benzyl-N-methyl-4-methylpiperdin-3-amine
  • Tofacitinib int-1 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
  • Tofacitinib intermediate 2
  • Tofacitinib Impurity 16
  • Cis-1-benzyl-4-methyl-3-methylamino-piperidine
  • Tofacitinib int
  • (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine
  • (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine ISO 9001：2015 REACH
  • 7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol
  • 477600-70-7