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Cyclodextrin

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Cyclodextrin, also called amylopectin, is a kind of oligosaccharide formed by the action of glucosyltransferase on starch. which is a compound that are formed by cyclic linkage of 6 to 8 molecules of D-glucose using alpha -1 and 4 bonds. Composed by 6 molecule glucose is calledα- cyclodextrin(α-CD), composed by 7 molecule glucose is called β-cyclodextrin (β-CD), and composed by 8 molecule glucose is calledγ- cyclodextrin (γ-CD). There are also composed by 9 to 10 glucose molecules. Cyclodextrin is a crystal, with a cylindrical structure, in the upper part of the cylinder (wide mouth) link –OH, in the bottom of the cylinder (the throat side) connected with a CH2OH base, so, as a whole cyclodextrin molecule is hydrophilic and soluble in water, and accordingly, it is hydrophobic within the cyclodextrin (inside the cylinder). Since it is ring-shaped, it does not have a reducing end. The cyclodextrin has certain stability to the acid, and it is difficult for ordinary amylase to hydrolysis. Various cyclodextrins and iodine color reaction is different. Specific rotation and solubility are not the same. The solubility ofβ- cyclodextrin is the smallest, the most easy to crystallize, and the most easy to separate. Because of its molecular cavity has a cavity, the diameter between 7 ~ 10A °, and the attracting effect of the intermolecular van Edward force can cause some gas, liquid or solid molecules to enter the cavity path to form the inclusion compound. Therefore, when the formation of inclusion compounds with traditional Chinese medicine, it can play a role in improving drug properties, improve drug stability, reduce side effects, increase bioavailability and so on. Such as naoliqing tablets contains a lot of borneol and mint, which are melted into viscous liquid, so that tablets is not qualified. There is no common melting phenomenon after the use of β-CD, so as to make the tablet quality meet the requirements.

Cyclodextrin is also a surfactant, can be used for food, as a stabilizer, can eliminate and cover special smell; improve food tissue structure; reduce and remove the bitter taste; antioxidant; envelope flavor, make it less volatile, the lasting fragrance; envelope edible pigment, make its stability; enhance the foaming effect of protein and so on; can be used for aquatic products, animal products, ice cream, sauces, dairy products. According to the size of the cyclodextrin hole, it can coordinate the cation with the same ionic radius, which can be used as phase transfer catalyst, analytical reagent and medicine. The envelope function of cyclodextrin is also applied to the pesticide, reduce the decomposition of pesticide, improve the efficacy, and used as emulsifier, deodorant and preservative for cosmetics, detergent for washing powder, and has a certain medical effect on acne.

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Structure:
Chemical Name:
Hydroxypropyl-beta-cyclodextrin
CAS:
94035-02-6
MF:
C54H102O39
Structure:
Chemical Name:
(2-Hydroxypropyl)-γ-cyclodextrin
CAS:
128446-34-4
MF:
C48H80-nO40.(C3H7O)n
Structure:
Chemical Name:
5,5'-isopropylidenebis(m-xylene-2,alpha,alpha'-triol)
CAS:
3957-22-0
MF:
C19H24O6
Structure:
Chemical Name:
1,2,4,5-Tetrakis(4-carboxyphenyl)benzene
CAS:
1078153-58-8
MF:
C34H22O8
Structure:
Chemical Name:
HYDROXYETHYL BETA-CYCLODEXTRIN
CAS:
128446-32-2
MF:
C56H98O42
Structure:
Chemical Name:
ALPHA-CYCLODEXTRIN HYDRATE
CAS:
51211-51-9
MF:
C36H62O31
Structure:
Chemical Name:
Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin
CAS:
67217-55-4
MF:
C49H76O37S
Structure:
Chemical Name:
TRIMETHYL-BETA-CYCLODEXTRIN
CAS:
55216-11-0
MF:
C63H112O35
Structure:
Chemical Name:
Betadex Sulfobutyl Ether Sodium
CAS:
182410-00-0
MF:
C42H70O35
Structure:
Chemical Name:
MONO-2-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN
CAS:
97227-32-2
MF:
C55H86O42S
Structure:
Chemical Name:
MONO-6-O-MESITYLENESULFONYL-GAMMA-CYCLODEXTRIN
CAS:
174010-62-9
MF:
C57H90O42S
Structure:
Chemical Name:
3A-Amino-3A-deoxy-(2AS,3AS)-alpha-cyclodextrin Hydrate
CAS:
121916-94-7
MF:
C36H61NO29
Chemical Name:
POLY-BETA-CYCLODEXTRIN
Structure:
Chemical Name:
3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin Hydrate
CAS:
189307-64-0
MF:
C48H81NO39
Structure:
Chemical Name:
MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN
CAS:
93184-10-2
MF:
C43H66O32S
Structure:
Chemical Name:
HYDROXYPROPYL-GAMMA-CYCLODEXTRIN
CAS:
99241-25-5
MF:
C72H128O48
Structure:
Chemical Name:
MONO-6-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN
CAS:
97227-33-3
MF:
C55H86O42S
Chemical Name:
2-hydroxypropyl-α-cyclodextrin
CAS:
128446-33-3
Structure:
Chemical Name:
Piroxicambeta-Cyclodextrin
CAS:
121696-62-6
MF:
C57H83N3O39S
Chemical Name:
SBE7-beta-CD
CAS:
194615-04-8
Structure:
Chemical Name:
HEXAKIS-6-IODO-6-DEOXY-ALPHA-CYCLODEXTRIN
CAS:
131105-41-4
MF:
C36H54I6O24
Structure:
Chemical Name:
OCTAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-GAMMA-CYCLODEXTRIN
CAS:
123155-06-6
MF:
C96H192O40Si8
Chemical Name:
monochlorotriazinyl--cyclodextrin
CAS:
187820-08-2
Structure:
Chemical Name:
piroxicam-beta-cyclodextrin
CAS:
96684-39-8
MF:
C57H83N3O39S
Chemical Name:
Sodium Sulphobutylether-Beta-Cyclodextrin
Structure:
Chemical Name:
α-Cyclodextrin, sulfated sodium salt
CAS:
699020-02-5
MF:
C36H62O34S
Chemical Name:
CYCLODEXTRIN
CAS:
12619-70-4
Structure:
Chemical Name:
Heptakis-O-(4-sulfobutyl)-beta-Cyclodextrin
CAS:
165133-56-2
MF:
C46H80O39S
Structure:
Chemical Name:
CARBOXYMETHYL BETA-CYCLODEXTRIN
CAS:
218269-34-2
MF:
C56H84O49
Chemical Name:
β-Cyclodextrin inclusion complex
Structure:
Chemical Name:
6-O-ALPHA-D-GLUCOSYL-ALPHA-CYCLODEXTRIN MONO
CAS:
10058-19-2
MF:
C42H70O35
Structure:
Chemical Name:
CYCLODEXTRIN
CAS:
85220-53-7
MF:
C54H90O45
Structure:
Chemical Name:
OCTAKIS-6-IODO-6-DEOXY-GAMMA-CYCLODEXTRIN
CAS:
168296-33-1
MF:
C48H72I8O32
Structure:
Chemical Name:
Glucose powder BP98 BP2000 USP24,25
MF:
C6H12O6
Chemical Name:
(2-Hydroxy-3-N,N,N-trimethylamino)propyl ^b-cyclodextrin chloride hydrate
Structure:
Chemical Name:
HEPTAKIS-6-BROMO-6-DEOXY-BETA-CYCLODEXTRIN
CAS:
53784-83-1
MF:
C42H63Br7O28
Structure:
Chemical Name:
Alprostadil alfadex
CAS:
55648-20-9
MF:
C56H94O35
Structure:
Chemical Name:
HEPTAKIS-6-IODO-6-DEOXY-BETA-CYCLODEXTRIN
CAS:
30754-23-5
MF:
C42H63I7O28
Structure:
Chemical Name:
HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN
CAS:
118646-79-0
MF:
C72H144O30Si6
Structure:
Chemical Name:
2,6-DI-O-METHYL-ALPHA-CYCLODEXTRIN
CAS:
51166-72-4
MF:
C48H84O30
Structure:
Chemical Name:
(2-HYDROXYPROPYL)-ALPHA-CYCLODEXTRIN
CAS:
99241-24-4
MF:
C54H96O36
Structure:
Chemical Name:
HEPTAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-BETA-CYCLODEXTRIN
CAS:
123155-03-3
MF:
C84H168O35Si7
Chemical Name:
Cyclodextrin glucanotransferase