2-hydroxypropyl-α-cyclodextrin Chemical Properties

Melting point:

245 °C (dec.)(lit.)

Density 

1.39 at 24.6℃

solubility 

Soluble in water, methanol, DMF. Insoluble in acetone, chloroform.

form 

Solid powder

color 

White to off white

optical activity

[α]20/D +125°, c = 1 in H2O

LogP

-10.6--9.89

Surface tension

66.1mN/m at 1g/L and 20℃

EPA Substance Registry System

.alpha.-Cyclodextrin, 2-hydroxypropyl ethers (128446-33-3)

Safety Information

WGK Germany 

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2-hydroxypropyl-α-cyclodextrin Usage And Synthesis

Uses

• (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
• It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
• Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
• It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.

General Description

(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.

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