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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Bortezomib Impurity 38
Chemical Name:
Edoxaban Impurity 27
Structure:
Chemical Name:
Linagliptin Impurity 30
CAS:
2074688-81-4
MF:
C33H32N8O5
Chemical Name:
Pantoprazole Impurity 8
Chemical Name:
Rivaroxaban Impurity 58
Chemical Name:
Rivaroxaban Impurity 65
Chemical Name:
Sitafloxacin Impurity 4
Chemical Name:
Ticagrelor Related Compound 83
Chemical Name:
Ticagrelor Related Compound 91
Chemical Name:
Vonoprazan Impurity 21
Structure:
Chemical Name:
Ceftazidime Oxide Impurity
CAS:
1301254-48-7
MF:
C22H22N6O8S2
Structure:
Chemical Name:
N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(4-methoxyphenoxy)propyl)piperazin-1-yl)acetamide
CAS:
1393717-46-8
MF:
C24H33N3O4
Chemical Name:
Atracurium Impurity 2
Chemical Name:
Blonanserin Impurity J
Chemical Name:
Brexpiprazole Impurity E
Chemical Name:
Cefazolin USP Impurity B
Chemical Name:
Everolimus Impurity D
Structure:
Chemical Name:
Loratadine Impurity I
CAS:
133330-56-0
MF:
C22H21ClN2O2
Chemical Name:
Olaparib Impurity Q
Chemical Name:
Ozagrel Impurity 3
Structure:
Chemical Name:
Pitavastatin Impurity 12
Chemical Name:
(6S,7S)-2-amino-6-(propylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ol
Structure:
Chemical Name:
Melphalan EP impurity H
CAS:
88457-23-2
MF:
C14H20Cl2N2O2
Structure:
Chemical Name:
ethyl 2-(4-(sec-butoxy)-3-formylphenyl)-4-methylthiazole-5- carboxylate
CAS:
2375033-31-9
MF:
C18H21NO4S
Structure:
Chemical Name:
Enrofloxacin EP Impurity C
CAS:
138892-82-7
MF:
C19H23N3O3
Structure:
Chemical Name:
Pregabalin Lactam (S)-Isomer Lactose Adduct
CAS:
466678-44-4
MF:
C20H35NO11
Structure:
Chemical Name:
Ertapenem Impurity Pro-maba
CAS:
724700-26-9
MF:
C12H14N2O3
Chemical Name:
Empagliflozin Impurity 22
Structure:
Chemical Name:
Empagliflozin Impurity 35
CAS:
1459754-40-5
MF:
C13H8ClIO2
Structure:
Chemical Name:
tirofiban
CAS:
464175-13-1
MF:
C9H18ClN
Chemical Name:
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-4,8,11-trifluoroacetyl- 1-yl)methyl)benzyl)-4,11-difluoroacetyl-1,4,8,11- tetraazacyclotetradecane
Structure:
Chemical Name:
Fulvestrant Impurity 4
CAS:
1621885-82-2
MF:
C30H44O6S
Structure:
Chemical Name:
Clopidogrel
CAS:
1360923-54-1
MF:
C16H16ClNO3S
Structure:
Chemical Name:
Ozagrel-015
CAS:
1332370-00-9
MF:
C10H10O3
Structure:
Chemical Name:
Piperacillin Sulfoxide
CAS:
67275-27-8
MF:
C23H27N5O8S
Structure:
Chemical Name:
Budesonide Impurity 11
CAS:
39672-76-9
MF:
C21H26O5
Structure:
Chemical Name:
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl) benzyl)-1,4,8,11-tetraazacyclotetradecane dodecahydrochloride
CAS:
2173049-85-7
MF:
C46H85ClN12
Structure:
Chemical Name:
Mirabegron Impurity 26
CAS:
91828-74-9
MF:
C8H9N3O4
Structure:
Chemical Name:
Alosetron Impurity 1
CAS:
1011293-30-3
MF:
C17H16N4O2
Structure:
Chemical Name:
2-(3-cyano-4-isobutoxyphenyl)-N,N,4-trimethylthiazole-5- carboxamide
CAS:
1380049-45-5
MF:
C18H21N3O2S
Chemical Name:
Acarbose Impurity F
Structure:
Chemical Name:
Oseltamivir Impurity 10
CAS:
2081110-43-0
MF:
C16H28N2O4
Chemical Name:
Pitavastatin Impurity 41
Structure:
Chemical Name:
Rivaroxaban Impurity 14
CAS:
1429334-02-0
MF:
C15H21N3O4
Chemical Name:
Ticagrelor Impurity 69
Chemical Name:
Tofacitinib Impurity 71
Chemical Name:
Tofacitinib Impurity 79
Structure:
Chemical Name:
Topiroxostat Impurity 5
CAS:
2050015-91-1
MF:
C7H6N4O
Structure:
Chemical Name:
Canagliflozin-10
CAS:
2161394-94-9
MF:
C24H25FO5S
Structure:
Chemical Name:
2-amino-N-(2-methylphenyl)-5-thiazolecarboxamide
CAS:
1184914-03-1
MF:
C11H11N3OS
Structure:
Chemical Name:
Afatinib Impurity 23
CAS:
1314777-66-6
MF:
C8H4FN3O3
Structure:
Chemical Name:
Atracurium Impurity 25
CAS:
86682-55-5
MF:
C20H25NO5
Chemical Name:
Aztreonam Impurity 7
Chemical Name:
Canagliflozin Impurity 43
Structure:
Chemical Name:
4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE OXIME
CAS:
152642-35-8
MF:
C16H13Cl2NO
Chemical Name:
Lucas
Chemical Name:
Afatinib Impurity M
Structure:
Chemical Name:
Ornidazole Impurity
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1100750-18-2
Structure:
Chemical Name:
4-(3-nitrophenyl)-3-Morpholinone
CAS:
845729-43-3
MF:
C10H10N2O4
Structure:
Chemical Name:
1,3-bis(2-chloroethyl)benzimidazolin-2-one
CAS:
55470-74-1
MF:
C11H12Cl2N2O
Chemical Name:
Nintedanib Impurity A (Intedanib Impurity A )
Structure:
Chemical Name:
Abiraterone Impurity 9
CAS:
165334-72-5
MF:
C24H31NO
Chemical Name:
Gliclazide Impurity A
Structure:
Chemical Name:
Medetomidine Impurity 14
CAS:
79924-14-4
MF:
C13H16N2
Structure:
Chemical Name:
Tenofovir Disoproxil Impurity B
CAS:
36817-69-3
MF:
C8H11N5O
Chemical Name:
Ipragliflozin IMP
Structure:
Chemical Name:
2-Propanone, 1,3-bis(4-methoxyphenyl)-
CAS:
29903-09-1
MF:
C17H18O3
Structure:
Chemical Name:
2-Hexenoic acid, 2-cyano-5-methyl-
CAS:
869-02-3
MF:
C8H11NO2
Structure:
Chemical Name:
CP-690550A
CAS:
1243290-37-0
MF:
C15H21N5O2
Structure:
Chemical Name:
(S)-Tomoxetine
CAS:
105314-53-2
MF:
C17H21NO
Structure:
Chemical Name:
Fexofenadine EP Impurity F
CAS:
185066-33-5
MF:
C31H37NO4
Structure:
Chemical Name:
(E)-2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)ethan-1-amine
CAS:
468104-18-9
MF:
C13H17NO
Structure:
Chemical Name:
4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)picolinamide
CAS:
1992028-94-0
MF:
C13H10N6O
Structure:
Chemical Name:
Indacaterol Impurity 22
CAS:
773895-24-2
MF:
C31H34N2O3
Structure:
Chemical Name:
10-O-2,2-Dichloroethoxycarbonyl Docetaxe
CAS:
158810-73-2
MF:
C46H55Cl2NO16
Structure:
Chemical Name:
4R,5S)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid
CAS:
849831-77-2
MF:
C16H13NO3
Structure:
Chemical Name:
PDXA-226
CAS:
352637-51-5
MF:
C14H14N2O
Structure:
Chemical Name:
Ropivacaine-ET-R
CAS:
98626-60-9
MF:
C16H24N2O
Structure:
Chemical Name:
Ropivacaine-iPr-S
CAS:
265120-58-9
MF:
C17H26N2O
Structure:
Chemical Name:
(S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine
CAS:
1384080-33-4
MF:
C19H21NOS
Structure:
Chemical Name:
methyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate
MF:
C17H15NO4S
Chemical Name:
Apremilast impurity 15
Structure:
Chemical Name:
Aprepitant Impurity 22
CAS:
934540-48-4
MF:
C20H16F7NO2
Structure:
Chemical Name:
Aprepitant Impurity 9
CAS:
219821-37-1
MF:
C24H25F7N4O4
Structure:
Chemical Name:
Betamethasone EP Impurity I
CAS:
185613-69-8
MF:
C22H29FO5
Structure:
Chemical Name:
Canagliflozin Impurity 14
CAS:
842133-17-9
MF:
C24H25FO5S
Chemical Name:
Carfilzomib Impurity F
Structure:
Chemical Name:
Cefamandole Impurity A
CAS:
1947364-12-6
MF:
C17H16N2O6S
Structure:
Chemical Name:
Dapagliflozin Impurity 19
CAS:
1469910-84-6
MF:
C29H33ClO10
Structure:
Chemical Name:
Carvedilol Impurity 2
CAS:
1198090-71-9
MF:
C18H17NO3
Chemical Name:
Clotrimazole Impurity 2
Chemical Name:
Dapagliflozin Impurity 33
Chemical Name:
Erlotinib Impurity 56
Structure:
Chemical Name:
Moxifloxacin Impurity 8
CAS:
1829588-19-3
MF:
C21H25N3O5
Structure:
Chemical Name:
Olaparib Impurity 30
CAS:
1460272-52-9
MF:
C24H21FN4O4
Chemical Name:
Pitavastatin Impurity 27
Chemical Name:
Pramipexole Impurity 24
Chemical Name:
Rocuronium Bromide Impurity 22
Structure:
Chemical Name:
Tolterodine Impurity 1
CAS:
88407-28-7
MF:
C22H31NO
Structure:
Chemical Name:
Voriconazole Impurity 7
CAS:
239807-04-6
MF:
C16H14F3N5O