Analytical Chemistry
Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.
According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.
(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.
Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.
Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.
The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.
With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.
Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:
1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.
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- Chemical Name:
- Clindamycin Impurity A
- Chemical Name:
- Tigecycline Impurity F
- Chemical Name:
- Fasudil iMpurity A
- Chemical Name:
- Cefminox Impurity C
- Chemical Name:
- Nicorandil Impurity E
- Chemical Name:
- Prednicarbate Impurity G
- Structure:
- Chemical Name:
- 4,5-Dibromo-1,2-benzenediol
- CAS:
- 2563-26-0
- MF:
- C6H4Br2O2
- Structure:
- Chemical Name:
- CLOPIDOGREL CARBOXYLIC ACID
- CAS:
- 144457-28-3
- MF:
- C15H14ClNO2S
- Structure:
- Chemical Name:
- RAC (CIS/TRANS) DONEPEZIL N-OXIDE
- CAS:
- 120013-84-5
- MF:
- C24H29NO4
- Structure:
- Chemical Name:
- 5-Carboxy-2'-deoxyuridine
- CAS:
- 14599-46-3
- MF:
- C10H12N2O7
- Chemical Name:
- Ipragliflozin Impurity 5
- Structure:
- Chemical Name:
- Alectinib Impurity
- CAS:
- 1256584-83-4
- MF:
- C26H25N3O2
- Structure:
- Chemical Name:
- Afatinib impurity 11/Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib
- CAS:
- 2223677-58-3
- MF:
- C22H20ClFN4O4
- Structure:
- Chemical Name:
- Ibrutinib Impurity 18
- CAS:
- 1881246-01-0
- MF:
- C16H12N4O
- Structure:
- Chemical Name:
- Vitamin B1 Impurity 6
- MF:
- C12H17ClN4OS
- Structure:
- Chemical Name:
- 5,5'-((tert-butylazanediyl)bis(1-hydroxyethane-2,1-diyl))bis(benzene- 1,3-diol)
- MF:
- C20H27NO6
- Structure:
- Chemical Name:
- 2,2'-difluoro-3,3'-dimethoxy-1,1'-biphenyl
- CAS:
- 2316733-82-9
- MF:
- C14H12F2O2
- Chemical Name:
- nicergoline impurity N
- Chemical Name:
- Nintedanib Impurity 26
- Chemical Name:
- N-Formyl impurity
- Structure:
- Chemical Name:
- (3R,4R)-N,1,4-trimethyl-N-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidin-3-amine
- CAS:
- 2227197-38-6
- MF:
- C14H21N5
- Chemical Name:
- Varenicline Impurity 1
- Structure:
- Chemical Name:
- Amlodipine Impurity 27 Disodium Salt
- CAS:
- 120289-11-4
- MF:
- C19H20ClNO7
- Chemical Name:
- Erlotinib Impurity 47 HCl
- Chemical Name:
- Etoricoxib Impurity 33
- Structure:
- Chemical Name:
- 2,2-dichloro-N-(2,3-dimethylphenyl)acetamide
- CAS:
- 18823-63-7
- MF:
- C10H11Cl2NO
- Structure:
- Chemical Name:
- 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
- CAS:
- 93413-76-4
- MF:
- C15H19NO2
- Structure:
- Chemical Name:
- Amoxicillin Impurity T
- MF:
- C16H19N3O5S
- Structure:
- Chemical Name:
- Clopidogrel Impurity 50
- MF:
- C15H14ClNO2S
- Chemical Name:
- PraMipexole IMpurity Z1/Z2
- Structure:
- Chemical Name:
- trans-Ibuprofen Impurity G
- MF:
- C13H18O2
- Chemical Name:
- Vonoprazan Impurity 15
- Chemical Name:
- Esomeprazole Impurity 6
- Chemical Name:
- Erlotinib Impurity 22
- Chemical Name:
- Teneligliptin Impurity 1
- Chemical Name:
- Erlotinib Hydrochloride iMpurity 51
- Structure:
- Chemical Name:
- (S)-10-(1-aminocyclopropyl)-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid formic acid
- MF:
- C17H18N2O6
- Structure:
- Chemical Name:
- 1H-Imidazole-1-ethanol, α-(chloromethyl)-5-nitro-
- CAS:
- 116989-52-7
- MF:
- C6H8ClN3O3
- Structure:
- Chemical Name:
- 4-Pyridinemethanol, 3-hydroxy-2,5-dimethyl-, hydrochloride (1:1)
- CAS:
- 875-26-3
- MF:
- C8H11NO2.ClH
- Chemical Name:
- Afatinib ImpurityOYQ
- Structure:
- Chemical Name:
- Androst-3-en-17-one,(5)
- CAS:
- 14935-81-0
- MF:
- C19H28O
- Chemical Name:
- Landiolol impurity X
- Chemical Name:
- 2-((4-(3-aminopiperidin-1-yl)
- Chemical Name:
- Rosuvastatin Impurity 111
- Structure:
- Chemical Name:
- Metoprolol IMpurity V
- MF:
- C15H25NO3
- Chemical Name:
- Teneligliptin Impurity 12
- Chemical Name:
- Nicergoline EP Impurity E
- Structure:
- Chemical Name:
- Hexanoic acid, 3-[(hydroxyamino)methyl]-5-methyl-, (3S)-
- CAS:
- 2349671-57-2
- MF:
- C8H17NO3
- Structure:
- Chemical Name:
- α-D-Glucopyranoside, methyl 1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, 2,3,4,6-tetraacetate
- CAS:
- 714269-58-6
- MF:
- C30H35ClO11
- Chemical Name:
- Caspofungin Impurity H
- Structure:
- Chemical Name:
- (trans)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-methoxyphenyl)-1-methylpiperidine hydrochloride
- CAS:
- 127017-41-8
- MF:
- C21H26ClNO4
- Structure:
- Chemical Name:
- Ezetimibe Impurity 76
- CAS:
- 1185883-46-8
- MF:
- C39H44F2N2O5Si
- Structure:
- Chemical Name:
- Cefmetazole impurity 9/(6R-cis)-7-[[[(Cyanomethyl)thio]acetyl]amino]-3-(hydroxymethyl)-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
- CAS:
- 70953-19-4
- MF:
- C13H15N3O6S2
- Structure:
- Chemical Name:
- ((cis)-4-(4-fluorophenyl)-1-methylpiperidin-3-yl)methyl 4-methylbenzenesulfonate
- MF:
- C20H24FNO3S
- Structure:
- Chemical Name:
- 7-Hydroxy Alosetron
- CAS:
- 863485-44-3
- MF:
- C17H18N4O2
- Structure:
- Chemical Name:
- Dolutegravir 2-Desfluoro Impurity
- CAS:
- 1863916-88-4
- MF:
- C20H20FN3O5
- Structure:
- Chemical Name:
- Moxifloxacin Impurity 46
- CAS:
- 1932499-97-2
- MF:
- C8H16N2
- Structure:
- Chemical Name:
- Posaconazole Impurity 43
- CAS:
- 1428118-40-4
- MF:
- C13H20N2O2
- Structure:
- Chemical Name:
- Empagliflozin Impurity 32
- CAS:
- 1620758-25-9
- MF:
- C24H29ClO8
- Structure:
- Chemical Name:
- Sugammadex Impurity 16
- CAS:
- 2412952-97-5
- MF:
- C69H108BrNaO46S7
- Structure:
- Chemical Name:
- 1,1'-(1,4,8,11-tetraazacyclotetradecane-1,11-diyl)bis(2,2,2- trifluoroethan-1-one) dihydrochloride
- MF:
- C14H24Cl2F6N4O2
- Structure:
- Chemical Name:
- 9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-(4-oxo-1,2,3,4-tetrahydro-1-pyridyl)-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
- CAS:
- 130539-72-9
- MF:
- C19H17FN2O4
- Structure:
- Chemical Name:
- Clopidogrel
- CAS:
- 444728-15-8
- MF:
- C15H15ClN2OS
- Structure:
- Chemical Name:
- (3R,5S)-5-((S)-8-fluoro-4-isopropyl-2-(N-methylmethyl sulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5- dihydroxypentanoate calcium(II)
- CAS:
- 854898-50-3
- MF:
- C44H54CaF2N6O12S2
- Structure:
- Chemical Name:
- Arbidol Impurity I
- CAS:
- 153633-10-4
- MF:
- C22H24Br2N2O3S
- Structure:
- Chemical Name:
- Palonosetron Impurity 9
- CAS:
- 2216755-75-6
- MF:
- C18H24N2O
- Chemical Name:
- Zopiclone Impurity 12
- Chemical Name:
- Selexipag impurity
- Structure:
- Chemical Name:
- 2-(3-formyl-4-isobutoxyphenyl)-N,N,4-trimethylthiazole- 5-carboxamide
- CAS:
- 1380049-42-2
- MF:
- C18H22N2O3S
- Chemical Name:
- Benidipine Impurity V
- Chemical Name:
- Apremilast Impurity OH
- Chemical Name:
- Atracurium Impurity T
- Chemical Name:
- Dextrorotation lansoprazole Impurity H
- Chemical Name:
- Dextrorotation lansoprazole Impurity M
- Chemical Name:
- lansoprazole Impurity 26
- Chemical Name:
- Lincomycin sulfone Impurity 2
- Chemical Name:
- Palbociclib Impurity 31
- CAS:
- 2955712-44-2
- Structure:
- Chemical Name:
- Parecoxib Impurity T
- CAS:
- 198471-83-9
- MF:
- C19H18N2O5S
- Chemical Name:
- Ropivacaine Impurity 31
- Chemical Name:
- Ropivacaine Impurity 40
- Chemical Name:
- Sugammadex sodium Decomposition process Impurity 3
- Chemical Name:
- Sugammadex sodium Org48301 Impurity
- Chemical Name:
- Topiroxostat Impurity Ⅱ-3
- Structure:
- Chemical Name:
- Ivabradine related compound 9
- CAS:
- 85175-49-1
- MF:
- C12H13NO4
- Chemical Name:
- Afatinib impurity 28
- Chemical Name:
- blonanserin impurity O
- Structure:
- Chemical Name:
- Butyphthalide impurity 42
- CAS:
- 952412-79-2
- MF:
- C10H12O3
- Chemical Name:
- Butyphthalide impurity 48
- Chemical Name:
- Dapoxetine impurity 20
- Chemical Name:
- Empagliflozin Impurity POE
- Chemical Name:
- Febuxostat Impurity 73
- Chemical Name:
- Febuxostat Impurity 78
- Structure:
- Chemical Name:
- Ibrutinib Impurity 21
- CAS:
- 1642571-08-1
- MF:
- C27H30N6O3
- Chemical Name:
- Lenvatinib Impurity 22
- Chemical Name:
- Moxifloxacin Impurity 47
- Chemical Name:
- Parecoxib sodium Impurity 35
- Structure:
- Chemical Name:
- Tofacitinib Impurity 20
- CAS:
- 1092578-44-3
- MF:
- C27H31N5O2S
- Chemical Name:
- Tofacitinib Impurity 88
- Chemical Name:
- Vildagliptin Impurity ZA9
- Chemical Name:
- Nintedanib Impurity K