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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure:
Chemical Name:
Astragalin 7-O-β-D-glucopyranoside
CAS:
25615-14-9
MF:
C27H30O16
Structure:
Chemical Name:
α,α-Dibromo-o-tolunitrile
CAS:
655-63-0
MF:
C8H5Br2N
Structure:
Chemical Name:
7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID
CAS:
79286-73-0
MF:
C11H8ClFN2O3
Structure:
Chemical Name:
HYDRIDE-L
CAS:
41639-74-1
MF:
C18H22O4
Structure:
Chemical Name:
2-Amino-4-trifluoromethoxybenzothiazole
CAS:
235101-36-7
MF:
C8H5F3N2OS
Structure:
Chemical Name:
7-Phenyl-acetamido-deacetoxy-cephalosporanic-acid
CAS:
27255-72-7
MF:
C16H16N2O4S
Structure:
Chemical Name:
O-PROPIONYLBENZOIC ACID
CAS:
2360-45-4
MF:
C10H10O3
Structure:
Chemical Name:
Triacetyl Aloe-emodin (Impurity A)
CAS:
25395-11-3
MF:
C21H16O8
Structure:
Chemical Name:
3-METHOXY-L-TYROSINE
CAS:
300-48-1
MF:
C10H13NO4
Structure:
Chemical Name:
(4S-cis)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CAS:
196085-85-5
MF:
C14H23NO4
Structure:
Chemical Name:
(3S,4S,6S)-3-Hexyl-3,4,5,6-tetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one
CAS:
68711-33-1
MF:
C22H42O3
Structure:
Chemical Name:
(3S,4S,6S)-3-Hexyl-3,4,5,6-tetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one
CAS:
68711-33-1
MF:
C22H42O3
Structure:
Chemical Name:
4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-
CAS:
68280-05-7
MF:
C14H14N2O
Structure:
Chemical Name:
4-N-Desacetyl-5-N-acetyl OseltaMivir
CAS:
956267-10-0
MF:
C16H28N2O4
Structure:
Chemical Name:
rac N-DesMethyl-N-(4-Methoxyphenethyl) Venlafaxine
CAS:
1346601-14-6
MF:
C25H35NO3
Structure:
Chemical Name:
11-Keto Oxcarbazepine
CAS:
537693-29-1
MF:
C15H10N2O3
Structure:
Chemical Name:
Isopropyl 4-(3-AMinophenyl)-1,4-dihydro-5-(2-Methoxyethoxycarbonyl)-2,6-diMethylpyridine-3-carboxylate
CAS:
155861-24-8
MF:
C21H28N2O5
Structure:
Chemical Name:
N1-Losartanyl-losartan (Losartan IMpurity)
CAS:
230971-71-8
MF:
C44H44Cl2N12O
Structure:
Chemical Name:
7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid
CAS:
127254-10-8
MF:
C19H18ClF2N3O3
Structure:
Chemical Name:
Sitagliptin Carbamoyl -D-Glucuronide
CAS:
940002-59-5
MF:
C23H23F6N5O9
Structure:
Chemical Name:
5-Hydroxy Desloratadine
CAS:
117811-12-8
MF:
C19H19ClN2O
Structure:
Chemical Name:
D-Streptamine, o-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N(sup 3)-(4-amino-2-hydroxybutyryl)-2-deoxy-
CAS:
50725-24-1
MF:
C22H43N5O13
Structure:
Chemical Name:
O-Benzyl Posaconazole
CAS:
170985-86-1
MF:
C44H48F2N8O4
Structure:
Chemical Name:
10-trans-Atorvastatin Acetonide tert-Butyl Ester
CAS:
1105067-90-0
MF:
C40H47FN2O5
Structure:
Chemical Name:
N-Trityl Candesartan Ethyl Ester
CAS:
856414-35-2
MF:
C45H38N6O3
Structure:
Chemical Name:
6α-Methyl Hydrocortisone 21-Acetate
CAS:
1625-11-2
MF:
C24H34O6
Structure:
Chemical Name:
N2-Losartanyl-losartan (Losartan IMpurity)
CAS:
230971-72-9
MF:
C44H44Cl2N12O
Structure:
Chemical Name:
N-Ethoxycarbonyl 7-ADCA
CAS:
72820-16-7
MF:
C11H14N2O5S
Structure:
Chemical Name:
(E)-Olopatadine
CAS:
113806-06-7
MF:
C21H23NO3
Structure:
Chemical Name:
NeMadipine B
CAS:
79925-38-5
MF:
C19H21Cl2NO4
Structure:
Chemical Name:
N-[(3,4-DiMethoxy-2-pyridinyl)Methyl] Pantoprazole
CAS:
957470-59-6
MF:
C24H24F2N4O6S
Structure:
Chemical Name:
4-Epi-6-epi Doxycycline
CAS:
97583-08-9
MF:
C22H24N2O8
Structure:
Chemical Name:
Sertraline-d3 hydrochloride
MF:
C17H15Cl3D3N
Structure:
Chemical Name:
Ethyl 3,4-O-Isopropylidene-5-O-methanesulfonylshikimate
CAS:
204254-84-2
MF:
C13H20O7S
Structure:
Chemical Name:
2-PyrazinecarboxaMide, N,N',N''-[2,4,6-boroxintriyltris[[(1R)-3-Methylbutylidene]iMino[(1S)-2-oxo-1-(phenylMethyl)-2,1-ethanediyl]]]tris-
CAS:
390800-88-1
MF:
C57H69B3N12O9
Structure:
Chemical Name:
(S,S)-1,7-diazatricyclo[7.3.0.07,11]dodecane-2,6,8,12-tetrone
CAS:
14842-41-2
MF:
C10H10N2O4
Structure:
Chemical Name:
1-Hydroxy-7-Methoxy-1,2,3,4-tetrahydronaphthalene
CAS:
32820-10-3
MF:
C11H14O2
Structure:
Chemical Name:
BroMhexine Hydrochloride iMpurity DN-(2-AMino-5-broMobenzyl)-N-MethylcyclohexanaMine Dihydrochloride
CAS:
132004-28-5
MF:
C14H21BrN2
Structure:
Chemical Name:
2-(DiMethylcarbaMoyl)benzoic acid, 97%
CAS:
20320-37-0
MF:
C10H11NO3
Structure:
Chemical Name:
RAC DESMETHYL CITALOPRAM HYDROCHLORIDE
CAS:
97743-99-2
MF:
C19H19FN2O
Structure:
Chemical Name:
rac-3-Oxo Atorvastatin SodiuM Salt
CAS:
1391052-00-8
MF:
C33H34FN2NaO5
Structure:
Chemical Name:
2-Demethoxy-4-methoxy urapidil
CAS:
34661-79-5
MF:
C20H29N5O3
Structure:
Chemical Name:
Ribavirin IMpurity F
CAS:
58151-87-4
MF:
C10H14N4O6
Structure:
Chemical Name:
4-[-((-((4-(5-(Bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoyl)oxy)ethyl)(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanic Acid
CAS:
1228551-91-4
MF:
C32H41Cl3N6O4
Structure:
Chemical Name:
3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride
CAS:
501120-42-9
MF:
C17H19ClN4O4S
Structure:
Chemical Name:
(3R,4S)-rel-3-[(1,3-Benzodioxol-5-yloxy)Methyl]-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-piperidine Hydrochloride
CAS:
1217655-87-2
MF:
C25H25ClFNO3
Structure:
Chemical Name:
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione
CAS:
216453-74-6
MF:
C25H32O6
Structure:
Chemical Name:
6(S)-Hydroperoxy Simvastatin
CAS:
149949-01-9
MF:
C25H38O7
Structure:
Chemical Name:
Russupteridine IV
CAS:
2535-20-8
MF:
C13H18N4O6
Structure:
Chemical Name:
2-[(1-Benzylpiperidin-4-yl)hydroxyMethyl]-5,6-diMethoxyindan-1-one
CAS:
197010-20-1
MF:
C24H29NO4
Structure:
Chemical Name:
5,6-trans-Ergocalciferol
CAS:
51744-66-2
MF:
C28H44O
Structure:
Chemical Name:
2-isonicotinoyl-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one
CAS:
923571-15-7
MF:
C17H15NO4
Structure:
Chemical Name:
4-(2-nitrophenyl)Morpholin-3-one
CAS:
845729-41-1
MF:
C10H10N2O4
Structure:
Chemical Name:
2-Naphthalenecarboxylic acid, 4-hydroxy-8-Methyl-
CAS:
16036-18-3
MF:
C12H10O3
Chemical Name:
RICE BRAN OIL
CAS:
68553-81-1
Structure:
Chemical Name:
3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-
CAS:
2402776-83-2
MF:
C16H17N7O2S
Chemical Name:
Iohexol ImpuritiesE
Chemical Name:
Bisoprolol Impurity 47
Chemical Name:
Gadobutrol Impurity 11(Ammonium salt)
Chemical Name:
Flomoxef Impurity F
Chemical Name:
Tegoprazan Impurity 15
Chemical Name:
Nirmatrelvir Impurity 8
Chemical Name:
Nirmatrelvir Impurity 2
Chemical Name:
Lasmiditan Impurity 9
Chemical Name:
Letermovir Impurity 2
Structure:
Chemical Name:
1H-Imidazole-2-carboxylic acid
CAS:
16042-25-4
MF:
C4H4N2O2
Chemical Name:
Olodaterol Impurity 19
Structure:
Chemical Name:
2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE
CAS:
29277-73-4
MF:
C14H20N2O2
Structure:
Chemical Name:
(-)-Nebivolol
CAS:
118457-16-2
MF:
C22H25F2NO4
Structure:
Chemical Name:
2-Hydroxymethyl Olanzapine
CAS:
174756-45-7
MF:
C17H20N4OS
Structure:
Chemical Name:
5-Hydroxymethyl Flucloxacillin
CAS:
75524-31-1
MF:
C19H17ClFN3O6S
Structure:
Chemical Name:
6-Hydroxy-5-methoxy-1-indanone
CAS:
90843-62-2
MF:
C10H10O3
Structure:
Chemical Name:
9-cis Acitretin
CAS:
419534-31-9
MF:
C21H26O3
Structure:
Chemical Name:
N-Desmethylvinblastine
CAS:
18172-50-4
MF:
C45H56N4O9
Structure:
Chemical Name:
Rabeprazole Sulfone
CAS:
117976-47-3
MF:
C18H21N3O4S
Structure:
Chemical Name:
3-Bromo Carbidopa
CAS:
1246819-09-9
MF:
C10H13BrN2O4
Structure:
Chemical Name:
(4S,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
CAS:
186508-95-2
MF:
C14H23NO4
Structure:
Chemical Name:
(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester
CAS:
125988-01-4
MF:
C11H17NO4
Structure:
Chemical Name:
(4-Carboxy-3-ethoxy)phenyl Acetic Acid (Repaglinide Impurity)
CAS:
220438-80-2
MF:
C11H12O5
Structure:
Chemical Name:
2-Chloromethyl-3,5-dimethylpyridin-4-ol
CAS:
220771-03-9
MF:
C8H10ClNO
Structure:
Chemical Name:
(3S,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester
CAS:
186508-94-1
MF:
C11H19NO4
Structure:
Chemical Name:
2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine
CAS:
717917-14-1
MF:
C19H19N3O2S
Structure:
Chemical Name:
(1R-4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]- 2-Cyclopentene-1-carboxylic acid methyl ester
CAS:
251326-99-5
MF:
C12H19NO4
Structure:
Chemical Name:
O-Isobutyryl (R)-Fesoterodine
CAS:
1208313-13-6
MF:
C30H43NO4
Structure:
Chemical Name:
Isopropyl Itraconazole
CAS:
89848-49-7
MF:
C34H36Cl2N8O4
Structure:
Chemical Name:
(R)-(-)-Ibuprofen-d3
CAS:
121702-86-1
MF:
C13H18O2
Structure:
Chemical Name:
(S,R,S,S)-Orlistat
CAS:
111466-63-8
MF:
C29H53NO5
Structure:
Chemical Name:
3R,4S-4-(4-methoxyphenyl)-1-methylpiperi dinyl] methanol
CAS:
127017-78-1
MF:
C14H21NO2
Structure:
Chemical Name:
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-
CAS:
188399-46-4
MF:
C12H15N5O3
Structure:
Chemical Name:
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE)
CAS:
141650-31-9
MF:
C19H22N2O5
Structure:
Chemical Name:
Valsartan cyano analog methyl ester
CAS:
137863-90-2
MF:
C25H30N2O3
Structure:
Chemical Name:
(8S)-2-BroMo α-Ergocryptine
CAS:
65700-36-9
MF:
C32H40BrN5O5
Structure:
Chemical Name:
3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone (Fenofibrate IMpurity)
CAS:
217636-47-0
MF:
C17H15ClO3
Structure:
Chemical Name:
5-(2-Chlorobenzyl)-thieno[3,2-c]pyridiniuM Chloride
CAS:
53885-64-6
MF:
C14H11Cl2NS
Structure:
Chemical Name:
ClarithroMycin 9-OxiMe
CAS:
103450-87-9
MF:
C38H70N2O13
Structure:
Chemical Name:
Desloratadine N-Hydroxypiperidine
CAS:
1193725-73-3
MF:
C19H19ClN2O
Structure:
Chemical Name:
O-DesMethyl Venlafaxine Cyclic IMpurity
CAS:
1346601-55-5
MF:
C16H23NO2
Structure:
Chemical Name:
rac-cis-2,3-Dichloro Sertraline Hydrochloride
CAS:
1198084-29-5
MF:
C17H18Cl3N
Structure:
Chemical Name:
11β-Hydroperoxy Dienogest
CAS:
106111-43-7
MF:
C20H25NO4
Structure:
Chemical Name:
2'-Nor ThiaMine
CAS:
7770-93-6
MF:
C11H15ClN4OS