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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Chemical Name:
Cefazolin USP Impurity D
Structure:
Chemical Name:
Cefuroxime Impurity 9
CAS:
2165460-37-5
MF:
C8H10N2O4S
Chemical Name:
Everolimus Impurity E
Chemical Name:
Peramivir Impurity 3
Chemical Name:
Peramivir Impurity 8
Structure:
Chemical Name:
Pitavastatin Impurity 13
Chemical Name:
Pramipexole Impurity R
Chemical Name:
Tadalafil Impuirty 21
Chemical Name:
Atracurium Impurity 26
Chemical Name:
Aztreonam Impurity 2
Structure:
Chemical Name:
Benazepril Impurity E
MF:
C24H28N2O5
Chemical Name:
Canagliflozin Impurity 44
Chemical Name:
Clotrimazole Impurity 3
Structure:
Chemical Name:
Dithio-Desethyl Carbodenafil
CAS:
1610830-81-3
MF:
C22H28N6OS2
Chemical Name:
Erlotinib Impurity 57
Chemical Name:
Esomeprazole Impurity 41
Chemical Name:
Oseltamivir Impurity 29
Chemical Name:
Pramipexole Impurity 36
Structure:
Chemical Name:
Riboflavin Impurity 1
CAS:
64480-68-8
MF:
C16H20N2O7
Chemical Name:
Rocuronium Bromide Impurity 10
Structure:
Chemical Name:
Rocuronium Bromide Impurity 23
MF:
C23H39NO3
Chemical Name:
Adefovir Impurity 10
Chemical Name:
Apremilast Impurity SY
Chemical Name:
Atracurium Impurity L
Chemical Name:
Cefoxitin EP Impurity G
Chemical Name:
Dextrorotation lansoprazole Impurity L
Chemical Name:
lansoprazole Impurity 25
Chemical Name:
Mirabegron Enantiomer Impurity
Chemical Name:
Ropivacaine Impurity 44
Chemical Name:
Ropivacaine Impurity 7
Chemical Name:
Sugammadex sodium Org199010-1 Impurity
Chemical Name:
Sugammadex sodium Org226100-1 Impurity
Chemical Name:
Afatinib impurity 32
Chemical Name:
Butyphthalide impurity 26
Chemical Name:
Butyphthalide impurity 32
Chemical Name:
Canagliflozin Impurity 30
Structure:
Chemical Name:
Celecoxib Impurity 20
CAS:
343853-74-7
MF:
C6H7N3O3S
Chemical Name:
Emtricitabine Impurity CFTU1
Chemical Name:
Esomeprazole Impurity 34
Chemical Name:
Febuxostat Impurity 82
Chemical Name:
Febuxostat Impurity 87
Chemical Name:
Gefitinib Impurity R
Structure:
Chemical Name:
Imatinib impurity 31
CAS:
1356565-47-3
MF:
C17H17N7
Chemical Name:
LCZ696(valsartan + sacubitril) impurity 33
Chemical Name:
Lenvatinib Impurity 26
Chemical Name:
Ozagrel impurity C
Chemical Name:
Regorafenib Impurity 24
Chemical Name:
Regorafenib Impurity 32
Chemical Name:
Sitafloxacin Impurity ZZ-A-01
Structure:
Chemical Name:
Solifenacin impurity 18
CAS:
1243274-83-0
MF:
C14H17NO3
Chemical Name:
Tofacitinib Impurity 87
Chemical Name:
Tofacitinib Impurity 92
Structure:
Chemical Name:
Amlodipine EP Impurity K
MF:
C26H31ClN2O8S
Chemical Name:
Febuxostat Impurity 49
Chemical Name:
ApreMilast IMpurity
Structure:
Chemical Name:
5'-broMo-[2,3'-bipyridin]-6'(1'H)-one
CAS:
381233-79-0
MF:
C10H7BrN2O
Structure:
Chemical Name:
1-((2R,3R)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
CAS:
2243786-01-6
MF:
C30H35N5O3
Chemical Name:
EMpagliflozin iMpurity 8
Structure:
Chemical Name:
EMpagliflozin iMpurity 13
CAS:
2125472-55-9
MF:
C23H25ClO8
Structure:
Chemical Name:
6-Methyldi(ondansetron-3-de(1,2-diMethyl-1H-iMidazole))
CAS:
1365727-07-6
MF:
C27H26N2O2
Structure:
Chemical Name:
ETHYL 3,4-EPOXYBUTANOATE
CAS:
32223-97-5
MF:
C6H10O3
Structure:
Chemical Name:
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
CAS:
69321-95-5
MF:
C9H12N2O7
Structure:
Chemical Name:
2-(ACETOXYMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE
CAS:
91219-90-8
MF:
C11H15NO3
Structure:
Chemical Name:
4,4'-(4H-1,2,4-TRIAZOL-4-YLMETHYLENE)BIS BENZONITRILE
CAS:
112809-52-6
MF:
C17H11N5
Structure:
Chemical Name:
Pregna-1,4,9(11)-triene-3,20-dione,21-(acetyloxy)-17-hydroxy-6-methyl-, (6a)-
CAS:
93239-37-3
MF:
C24H30O5
Chemical Name:
Tadalafil EP impurity E
Structure:
Chemical Name:
TF-A
CAS:
134965-85-8
MF:
C12H7ClN6
Structure:
Chemical Name:
myricetin 3-O-β-D-xylopyranosyl(1-2)-β-D-glucopyranoside
CAS:
142449-93-2
MF:
C26H28O17
Structure:
Chemical Name:
(S)-1-(2-Aminoacetyl)-pyrrolidine-2-carbonitrile
CAS:
914070-99-8
MF:
C7H11N3O
Structure:
Chemical Name:
N-[[2-(1H-Tetrazol-5-Yl)[1,1-Biphenyl]-4-Yl]Methyl]Amine(WXC00176)
CAS:
147225-68-1
MF:
C14H13N5
Structure:
Chemical Name:
MFFANMLJBOSKIX-UHFFFAOYSA-N
CAS:
352457-34-2
MF:
C9H13N5O2
Structure:
Chemical Name:
4,4',4''-Methylidenetrisbenzonitrile
CAS:
113402-31-6
MF:
C22H13N3
Structure:
Chemical Name:
methyl (2E)-3-(methylamino)but-2-enoate
CAS:
21759-69-3
MF:
C6H11NO2
Structure:
Chemical Name:
Entecavir Impurity 5
CAS:
84868-56-4
MF:
C21H20O2
Structure:
Chemical Name:
Bisoprolol-d5
CAS:
1189881-87-5
MF:
C18H31NO4
Structure:
Chemical Name:
4-(2-HYDROXY-3-ISOPROPYLAMINO-PROPOXY)-BENZOIC ACID METHYL ESTER
CAS:
33947-97-6
MF:
C14H21NO4
Structure:
Chemical Name:
3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2-[1-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]pentan-2-yl]-1,3-diazaspiro[4.4]non-1-en-4-one
CAS:
1346598-52-4
MF:
C39H38N10O
Structure:
Chemical Name:
5-METHYL-3-NITROMETHYL-HEXANOIC ACID
CAS:
181289-21-4
MF:
C8H15NO4
Structure:
Chemical Name:
4(3,4-DICHLOROPHENYL)1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENE AMINE RACEMATE
CAS:
140631-53-4
MF:
C17H17Cl2N
Structure:
Chemical Name:
(3R,5R)-tert-butyl 7-(2,3-bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS:
2588261-40-7
MF:
C37H42F2N2O5
Structure:
Chemical Name:
(S)-ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate
CAS:
870695-39-9
MF:
C8H13NO4
Structure:
Chemical Name:
4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-hydroxybenzyl)phthalazin-1(2H)-one
MF:
C24H24N4O4
Structure:
Chemical Name:
Diquafosol Impurity 2
CAS:
63785-59-1
MF:
C18H25N4O20P3
Structure:
Chemical Name:
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2,2'-dichloro-N-methyl-7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-amine
CAS:
2459302-87-3
MF:
C26H26Cl2N8
Structure:
Chemical Name:
(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2,2-dichloroacetyl) -2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
CAS:
1598416-08-0
MF:
C22H18Cl2N2O5
Structure:
Chemical Name:
PANTOPRAZOLE N-OXIDE SODIUM SALT
CAS:
1279822-90-0
MF:
C16H16F2N3NaO5S
Structure:
Chemical Name:
3-HYDROXY-THIOBENZAMIDE
CAS:
104317-54-6
MF:
C7H7NOS
Structure:
Chemical Name:
Tadalafil impurity 38
CAS:
185750-07-6
MF:
C14H15ClN2O3
Chemical Name:
Fulvestrant impurity H
Structure:
Chemical Name:
Trans-5-(Benzyloxyamino)piperidine-2-carboxylic acid,sodium salt
CAS:
2122800-38-6
MF:
C13H19N2NaO3
Structure:
Chemical Name:
1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate
CAS:
928615-46-7
MF:
C17H16FN3O2S
Structure:
Chemical Name:
2-METHYLPYRAZINE 1,4-DIOXIDE
CAS:
32046-26-7
MF:
C5H6N2O2
Structure:
Chemical Name:
4-AMINO-1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLIC ACID AMIDE
CAS:
247583-78-4
MF:
C8H14N4O
Structure:
Chemical Name:
CAPECITABINE-D11
CAS:
1132662-08-8
MF:
C15H13D11FN3O6
Structure:
Chemical Name:
Budesonide Impurity 6
CAS:
131918-73-5
MF:
C21H26O6
Structure:
Chemical Name:
Timolol Impurity 1
CAS:
75014-25-4
MF:
C13H24N4O5S
Structure:
Chemical Name:
Telmisartan EP-J
CAS:
885045-90-9
MF:
C33H29ClN4O2
Structure:
Chemical Name:
Pitavastatin Impurity 29
CAS:
148516-15-8
MF:
C25H20FNO2
Structure:
Chemical Name:
Rosuvastatin Related Compound 6
CAS:
521973-99-9
MF:
C13H23ClO4
Structure:
Chemical Name:
Medetomidine impurity
CAS:
2250243-44-6
MF:
C20H22N2O