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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure:
Chemical Name:
Omarigliptin Impurity
CAS:
1819364-01-6
MF:
C16H18F2N4O
Structure:
Chemical Name:
Palbociclib Impurity 8
CAS:
827022-31-1
MF:
C31H41N7O4
Structure:
Chemical Name:
Sitagliptin EP Impurity C
CAS:
1345822-86-7
MF:
C16H19F5N5O5P
Chemical Name:
Trifluridine Impurity
CAS:
2086328-10-9
Chemical Name:
Valsartan related compound H
Structure:
Chemical Name:
Vildagliptin Related Compound H
CAS:
2253194-13-5
MF:
C12H16N4O
Chemical Name:
Moxifloxacin Impurity 7
Structure:
Chemical Name:
(R)-6-Benzyloxy-8-(oxiran-2-yl)-4H-benzo[1,4]oxazin-3-one
CAS:
869478-12-6
MF:
C17H15NO4
Structure:
Chemical Name:
Merariveron impurity D
MF:
C26H28N6O3S2
Chemical Name:
Cefazolin impurity E
Chemical Name:
Lamivudine Impurity Mixture
Structure:
Chemical Name:
Rifaximin impurity B
CAS:
1351775-04-6
MF:
C43H49N3O11
Structure:
Chemical Name:
4-(3-(Piperidin-1-yl)propoxy)benzoic acid
CAS:
767286-87-3
MF:
C15H21NO3
Structure:
Chemical Name:
5-Chloro-3-sulfino-2-thiophenecarboxylic acid
CAS:
187746-97-0
MF:
C5H3ClO4S2
Structure:
Chemical Name:
ethyl (S)-10-fluoro-3-methyl-7-oxo- 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
CAS:
431058-46-7
MF:
C15H14FNO4
Structure:
Chemical Name:
methyl (Z)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
MF:
C24H21N3O3
Structure:
Chemical Name:
Isavuconazole Impurity 11
CAS:
2732924-99-9
MF:
C10H16ClN3O2
Structure:
Chemical Name:
Levosimendan Impurity 2
CAS:
103416-88-2
MF:
C11H12N2O2
Structure:
Chemical Name:
Aprepitant EP Impurity B
CAS:
2206606-86-0
MF:
C29H25F7N4O3
Structure:
Chemical Name:
Famotidine EP Impurity A
CAS:
88061-72-7
MF:
C8H15N7O2S3
Structure:
Chemical Name:
Meloxicam EP Impurity D
CAS:
1331636-17-9
MF:
C16H17N3O4S2
Structure:
Chemical Name:
Erythromycin Impurity
CAS:
40554-78-7
MF:
C37H65NO12
Structure:
Chemical Name:
Fluconazole EP Impurity I
CAS:
150168-54-0
MF:
C13H14BrF2N7O
Structure:
Chemical Name:
1-benzyl-2-methyl-1H-imidazole-carbaldehyde
CAS:
39269-74-4
MF:
C12H12N2O
Structure:
Chemical Name:
Sacubitril Impurity
CAS:
1015037-46-3
MF:
C23H27NO4
Structure:
Chemical Name:
Desloratadine Impurity
CAS:
50603-12-8
MF:
C20H21N
Chemical Name:
Olaparib Impurity H
Chemical Name:
Brexpiprazole Impurity B
Chemical Name:
Dapoxetine iMpurity 6
Structure:
Chemical Name:
Irbesartan Impurity 4
MF:
C25H28N6O
Structure:
Chemical Name:
2-cyclopentylidene-2-phenylacetic acid
MF:
C13H14O2
Chemical Name:
Cabozantinib impurity B
Structure:
Chemical Name:
Metoprolol IMpurity 3
MF:
C15H25NO3
Chemical Name:
Mirabegron Impurity 1
Structure:
Chemical Name:
Desfluoro Pitavastatin Calcium
CAS:
847849-67-6
MF:
C25H25NO4
Structure:
Chemical Name:
Plerixafor
CAS:
548488-49-9
MF:
C12H23F3N4O
Chemical Name:
Vonoprazan Impurity 10
Chemical Name:
Vonoprazan Impurity 5
Chemical Name:
Sitagliptin IMpurity 1
Chemical Name:
Etoricoxib Impurity 7
Chemical Name:
Ezetimibe Impurity D
Chemical Name:
Alogliptin Imp.13
Chemical Name:
Erlotinib Imp.18
Structure:
Chemical Name:
Ezetimibe (RSS)-Isomer
CAS:
1478664-18-4
MF:
C24H21F2NO3
Chemical Name:
Apremilast Impurity 6
Structure:
Chemical Name:
Azilsartan Impurity 16
CAS:
1417576-00-1
MF:
C28H20N4O8
Structure:
Chemical Name:
Regorafenib Impurity 11
CAS:
2512204-88-3
MF:
C19H18ClFN4O3
Structure:
Chemical Name:
Topiroxostat Impurity 2
CAS:
445218-61-1
MF:
C12H11N5O
Structure:
Chemical Name:
Fluvastatin Impurity 1
MF:
C24H26FNO4
Chemical Name:
Lornoxicam Impurity 7
Structure:
Chemical Name:
Prednisolone Impurity A
MF:
C21H28O5
Structure:
Chemical Name:
Tofacitinib Impurity 6
CAS:
1640972-35-5
MF:
C16H22N6O
Chemical Name:
Afatinib Impurity 20
Structure:
Chemical Name:
1-(4-Ethylphenyl)-2-methyl-2-propen-1-one
CAS:
70639-76-8
MF:
C12H14O
Structure:
Chemical Name:
O-PROPIONYLBENZOIC ACID
CAS:
2360-45-4
MF:
C10H10O3
Structure:
Chemical Name:
3-METHOXY-L-TYROSINE
CAS:
300-48-1
MF:
C10H13NO4
Structure:
Chemical Name:
(4S-cis)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CAS:
196085-85-5
MF:
C14H23NO4
Structure:
Chemical Name:
(3S,4S,6S)-3-Hexyl-3,4,5,6-tetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one
CAS:
68711-33-1
MF:
C22H42O3
Structure:
Chemical Name:
(3S,4S,6S)-3-Hexyl-3,4,5,6-tetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one
CAS:
68711-33-1
MF:
C22H42O3
Structure:
Chemical Name:
Triacetyl Aloe-emodin (Impurity A)
CAS:
25395-11-3
MF:
C21H16O8
Structure:
Chemical Name:
2,4'-Diamino[sulfonylbisbenzene]
CAS:
27147-69-9
MF:
C12H12N2O2S
Structure:
Chemical Name:
2-P-TOLYLOXYMETHYL-OXIRANE
CAS:
2186-24-5
MF:
C10H12O2
Structure:
Chemical Name:
3-Hydroxyazobenzene
CAS:
2437-11-8
Structure:
Chemical Name:
Astragalin 7-O-β-D-glucopyranoside
CAS:
25615-14-9
MF:
C27H30O16
Structure:
Chemical Name:
4-(5-CHLORO-2-THIENYL)-1,3-THIAZOL-2-AMINE
CAS:
123971-45-9
MF:
C7H5ClN2S2
Structure:
Chemical Name:
2-Amino-4-trifluoromethoxybenzothiazole
CAS:
235101-36-7
MF:
C8H5F3N2OS
Structure:
Chemical Name:
7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid
CAS:
127254-10-8
MF:
C19H18ClF2N3O3
Structure:
Chemical Name:
Sitagliptin Carbamoyl -D-Glucuronide
CAS:
940002-59-5
MF:
C23H23F6N5O9
Structure:
Chemical Name:
5-Hydroxy Desloratadine
CAS:
117811-12-8
MF:
C19H19ClN2O
Structure:
Chemical Name:
D-Streptamine, o-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N(sup 3)-(4-amino-2-hydroxybutyryl)-2-deoxy-
CAS:
50725-24-1
MF:
C22H43N5O13
Structure:
Chemical Name:
(S,R,S,S)-Orlistat
CAS:
111466-63-8
MF:
C29H53NO5
Structure:
Chemical Name:
N-Trityl Candesartan Ethyl Ester
CAS:
856414-35-2
MF:
C45H38N6O3
Structure:
Chemical Name:
3R,4S-4-(4-methoxyphenyl)-1-methylpiperi dinyl] methanol
CAS:
127017-78-1
MF:
C14H21NO2
Structure:
Chemical Name:
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-
CAS:
188399-46-4
MF:
C12H15N5O3
Structure:
Chemical Name:
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE)
CAS:
141650-31-9
MF:
C19H22N2O5
Structure:
Chemical Name:
Valsartan cyano analog methyl ester
CAS:
137863-90-2
MF:
C25H30N2O3
Structure:
Chemical Name:
(8S)-2-BroMo α-Ergocryptine
CAS:
65700-36-9
MF:
C32H40BrN5O5
Chemical Name:
Ceftriaxone Sodium impurity
Chemical Name:
Clarithromycin impurity
Structure:
Chemical Name:
Ivabradine Impurity 5
CAS:
1462470-54-7
MF:
C27H38N2O6
Structure:
Chemical Name:
Aprepitant Impurity 6
CAS:
170902-81-5
MF:
C23H21F7N4O3
Structure:
Chemical Name:
(S)-3-((R)-5-(4-fluorophenyl)-5-hydroxy-2-((E)-4-hydroxybenzylidene)pentanoyl)-4-phenyloxazolidin-2-one
MF:
C27H24FNO5
Structure:
Chemical Name:
Alogliptin Related Compound 14
CAS:
1820685-30-0
MF:
C18H23N5O3
Structure:
Chemical Name:
(3S,5S)-Atorvastatin (sodium salt)
CAS:
1428118-38-0
MF:
C33H36FN2NaO5
Structure:
Chemical Name:
Chlorpromazine EP impurity B
CAS:
19077-20-4
MF:
C21H28ClN3S
Structure:
Chemical Name:
2-amino-4-fluoro-5-nitrobenzoic acid
CAS:
1194097-41-0
MF:
C7H5FN2O4
Structure:
Chemical Name:
Alogliptin benzoate impurity K
CAS:
1618644-32-8
MF:
C25H25N5O3
Structure:
Chemical Name:
Belinostat Z-isomer
CAS:
1884227-58-0
MF:
C15H14N2O4S
Chemical Name:
Canagliflozin Impurity 13
Chemical Name:
Carfilzomib Impurity 1
Structure:
Chemical Name:
Dapagliflozin Impurity 14
CAS:
2271248-78-1
MF:
C21H25ClO6
Chemical Name:
Ibrutinib Impurity 13
Structure:
Chemical Name:
Linagliptin Impurity 26
CAS:
2446799-71-7
MF:
C20H17BrN6O2
Chemical Name:
Nintedanib Impurity 13 (Intedanib Impurity 13)
Structure:
Chemical Name:
vildagliptin Impurity E
CAS:
1789703-37-2
MF:
C17H25N3O2
Structure:
Chemical Name:
Sitagliptin Impurity 1
CAS:
823817-55-6
MF:
C16H15F6N5O
Structure:
Chemical Name:
Niraparib metabolite M1
CAS:
1476777-06-6
MF:
C19H19N3O2
Structure:
Chemical Name:
Amlodipine Impurity 16
MF:
C26H31ClN2O8S
Structure:
Chemical Name:
Edoxaban Impurity 11 (1R,2R,4S)
CAS:
480451-98-7
MF:
C21H30ClN5O5
Structure:
Chemical Name:
Rivaroxaban Impurity 25
CAS:
931117-61-2
MF:
C19H21Cl2N3O6S