Basic information Safety Supplier Related

Cafedrine

Basic information Safety Supplier Related

Cafedrine Basic information

Product Name:
Cafedrine
Synonyms:
  • Cafedrine
  • 3,7-Dihydro-7-[2-[(2-hydroxy-1-methyl-2-phenylethyl)amino]ethyl]-1,3-dimethyl-1H-purine-2,6-dione
  • 7-[2-(β-Hydroxy-α-methylphenethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
  • 7-(2-((Alphas,betar)-beta-hydroxy-alpha-methylphenethylamino)ethyl)-1,3-dimethyl-2,6(1H,3H)purindion
  • 7-(2-(2-Hydroxy-1-methylphenethylamino)ethyl)theophylline
  • 7-(2-{[(1R,2S)-1-Hydroxy-1-phenyl-2-propanyl]amino}ethyl)-1,3-dim ethyl-3,7-dihydro-1H-purine-2,6-dione
  • 7-(2-(beta-Hydroxy-alpha-methylphenethylamino)ethyl)theophylline
  • Brn 0583473
CAS:
58166-83-9
MF:
C18H23N5O3
MW:
357.412
Mol File:
58166-83-9.mol
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Cafedrine Chemical Properties

Boiling point:
591.6±52.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
pka
13.90±0.20(Predicted)
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Cafedrine Usage And Synthesis

Originator

Praxinor,Merck Lipha Sante

Uses

(-)-Cafedrine is composed of linked Phenylpropanolamine (P336100) and Theophylline (T343850). It is used to regulate and restore blood pressure.

Manufacturing Process

7.5 g 7-(2-bromethyl)theophylline, 11.3 g 1-norphedrine and 12.5 ml isopropanol were refluxed with stirring for 6 hours. Then 30 ml ethanol and HCl in ethanol to pH 5-6 were added. The mixture stood for 2 days. 9.6 g of 7-(2-(beta-hydroxy-alpha-methylphenethylamino)ethyl)theophylline hydrochloride was filtered off and dried. MP 243°-244°C.
In practice it is usually used as free base.

Therapeutic Function

Analeptic

CafedrineSupplier

TargetMol Chemicals Inc.
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