Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Basic information
- Product Name:
- Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
- Synonyms:
-
- Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
- Xanthine oxidase-IN-5
- CAS:
- 2276711-87-4
- MF:
- C18H16FN3O3
- MW:
- 341.34
- Mol File:
- 2276711-87-4.mol
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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Chemical Properties
- Boiling point:
- 558.8±60.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- pka
- 0.30±0.12(Predicted)
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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Usage And Synthesis
Uses
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].
in vivo
Xanthine oxidase-IN-5 (compound 9m) shows potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate[1].
| Animal Model: | Potassium oxonate-induced hyperuricemic rat model[1] |
| Dosage: | 20 mg/kg |
| Administration: | PO; single (measured serum uric acid after 0.5 - 8 hours) |
| Result: | Showed potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate. |
References
[1] Zhang TJ, Zhang Y, Zhang ZH, et al. Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2022;60:128582. DOI:10.1016/j.bmcl.2022.128582
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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-(2276711-87-4)Related Product Information
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