Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)- Basic information
- Product Name:
- Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
- Synonyms:
-
- Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
- Xanthine oxidoreductase-IN-3
- N-(4-Chlorophenyl)-4-(1H-tetrazol-5-yl)benzamide
- CAS:
- 651769-78-7
- MF:
- C14H10ClN5O
- MW:
- 299.7151
- Mol File:
- 651769-78-7.mol
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Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)- Usage And Synthesis
Uses
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].
in vivo
Xanthine oxidoreductase-IN-3 (compound IIIa) (5 mg/kg; p.o.) shows a uric acid-lowering effect from 3 h after administration in mice with acute hyperuricemia[1].
| Animal Model: | ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] |
| Dosage: | 5 mg/kg |
| Administration: | Suspended in 0.5% CMC-Na solution for intragastric administration |
| Result: | Showed a uric acid-lowering effect from 3 h after administration. |
References
[1] Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947
Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-Supplier
Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Bide Pharmatech Ltd.
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- 400-1647117 13681763483
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Henan Alpha Chemical Co., Ltd.
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- 0371-55013243 15324716602
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Shanghai Yifei Biotechnology Co. , Ltd.
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- 021-65675885 18964387627
- customer_service@efebio.com
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