Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Basic information
- Product Name:
- Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
- Synonyms:
-
- Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
- Xanthine oxidase-IN-4
- CAS:
- 2642137-96-8
- MF:
- C15H13N5O2
- MW:
- 295.3
- Mol File:
- 2642137-96-8.mol
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Chemical Properties
- Boiling point:
- 404.2±45.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- pka
- 5.93±0.20(Predicted)
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Usage And Synthesis
Uses
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].
in vivo
Xanthine oxidase-IN-4 (compound 19a) (SD rats, 10 mg/kg, Intragastrically, once) significantly reduces the serum concentration of uric acid[1].
| Animal Model: | Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intragastrically, once |
| Result: | Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%. |
References
[1] Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086. DOI:10.1016/j.ejmech.2021.114086
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