isodiospyrin Chemical Properties

Melting point:

233 °C

Boiling point:

712.0±60.0 °C(Predicted)

Density 

1.495±0.06 g/cm3(Predicted)

pka

5.66±0.20(Predicted)

form 

Solid

color 

Orange to red

isodiospyrin Usage And Synthesis

Uses

Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].

Definition

ChEBI: Isodiospyrin is a member of biphenyls.

IC 50

Topoisomerase I

References

[1] Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. DOI:10.1016/j.bcp.2003.07.003
[2] B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. DOI:10.1002/(sici)1099-1573(200003)14:2<112::aid-ptr488>3.0.co;2-t
[3] Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. DOI:10.1002/cbdv.201000310

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