(3-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE Chemical Properties

Melting point:

69-72°C

Boiling point:

321.2±25.0 °C(Predicted)

Density 

1.499±0.06 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture

Appearance

White to light yellow Solid

Sensitive 

Moisture Sensitive

CAS DataBase Reference

24974-73-0

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-34-22

Safety Statements 

26-36/37/39

RIDADR 

3261

HazardClass 

8

PackingGroup 

II

MSDS

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(3-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE Usage And Synthesis

Uses

3-Chloro-alpha-toluenesulfonyl chloride is used as a pharmaceutical intermediate.

Synthesis

(3-Chlorophenyl)methanesulfonyl chloride was prepared as follows: thiourea (0.387 g, 5 mmol) and m-chlorobenzyl chloride (5 mmol) were dissolved in 5 mL of ethanol, and the reaction was carried out at reflux for 30 min, then the solvent was removed under reduced pressure to obtain a white solid. This white solid was slowly added dropwise to a mixed system of NaClO2 (1.61 g, 15 mmol, 85% purity), concentrated HCl (3 mL) and MeCN (10 mL). The temperature in the reaction system was controlled between 10 and 20oC with a water bath during the addition process. After the addition was completed, the reaction was continued with stirring for 30 min, the acetonitrile was removed under low temperature and under reduced pressure, 25 mL of water was added, and the solids in the system were filtered and dried to obtain the product colorless crystals of (3-chlorophenyl)methanesulfonyl chloride with a melting point of 76-78oC, 1.035 g, and a yield of 92%.

(3-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE(24974-73-0)Related Product Information

• Butyltriphenylphosphonium chloride
• Phenylmethylsulfonyl fluoride
• Tosyl chloride
• Methanesulfonyl chloride
• (2-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE
• (4-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE
• (3-CHLORO-PHENYL)-METHANESULFONYL CHLORIDE
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• (3,4-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE