5-Chloro-2-nitroaniline Chemical Properties

Melting point:

125-129 °C (dec.)(lit.)

Boiling point:

200°C (rough estimate)

Density 

1.5610 (rough estimate)

refractive index 

1.5870 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Chloroform, Methanol

form 

Liquid

pka

-1.46±0.25(Predicted)

color 

Clear colorless to light yellow

BRN 

2210201

InChIKey

ZCWXYZBQDNFULS-UHFFFAOYSA-N

CAS DataBase Reference

1635-61-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

T+,N,T

Risk Statements 

26/27/28-33-51/53

Safety Statements 

28-36/37-45-61-28A

RIDADR 

UN 2237 6.1/PG 3

WGK Germany 

3

F 

9-23

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214210

MSDS

• Language:English Provider:5-Chloro-2-nitrobenzenamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Chloro-2-nitroaniline Usage And Synthesis

Description

2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect.

Preparation

Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%.

Chemical Properties

yellow to orange powder

Uses

5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity.

Uses

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.

Application

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

General Description

The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

5-Chloro-2-nitroaniline(1635-61-6)Related Product Information

• 2-Nitroaniline
• 4-Chlorobenzenamine hydrochloride
• 3,4-Dichloroaniline
• 3,5-Dichloroaniline
• 4-Chloroaniline
• 5-Chloro-2-methylaniline
• 2-Chloroaniline
• 4-Nitroaniline
• 4-CHLORO-2-NITROANILINE
• 3-Chloroaniline
• 2,5-Dichloroaniline
• N-Methyl-4-nitroaniline
• DICHLORPHENAMIDE BULK POWDER
• 5-CHLORO-2-NITRODIPHENYLAMINE
• N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE
• N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
• 5-CHLORO-4-METHYL-2-NITROANILINE
• 3-CHLORO-2-NITROANILINE