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Methylglyoxal 1,1-dimethyl acetal

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Methylglyoxal 1,1-dimethyl acetal Basic information

Product Name:
Methylglyoxal 1,1-dimethyl acetal
Synonyms:
  • PYRUVIC ALDEHYDE DIMETHYL ACETAL
  • PYRUVALDEHYDE DIMETHYLACETAL
  • PYRUVALDEHYDE 1,1-DIMETHYL ACETAL
  • PYRUVALDEHYDE-1-DIMETHYL ACETAL
  • Methylglyoxal dimethyl acetal~Pyruvaldehyde dimethyl acetal
  • PYRUVIC ALDEHYDE DIMETHYL ACETAL, 97+%
  • PYRUVIC ALDEHYDE DIMETHYL ACETAL 98%
  • PYRUVIC ALDEHYDE DIMETHYL ACETAL(INTERMEDIATE OF B-CAROTENE)
CAS:
6342-56-9
MF:
C5H10O3
MW:
118.13
EINECS:
228-735-4
Product Categories:
  • ACETYLGROUP
  • Aldehydes
  • blocks
  • BuildingBlocks
  • ketone
  • (intermediate of -carotene)
Mol File:
6342-56-9.mol
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Methylglyoxal 1,1-dimethyl acetal Chemical Properties

Melting point:
-57 °C
Boiling point:
143-147 °C(lit.)
Density 
0.976 g/mL at 25 °C(lit.)
vapor pressure 
11hPa at 20℃
refractive index 
n20/D 1.398(lit.)
Flash point:
100 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Liquid
color 
Clear colorless to yellow
Water Solubility 
MISCIBLE
BRN 
1560557
InChIKey
ULVSHNOGEVXRDR-UHFFFAOYSA-N
LogP
-0.199 (est)
CAS DataBase Reference
6342-56-9
NIST Chemistry Reference
2-Propanone, 1,1-dimethoxy-(6342-56-9)
EPA Substance Registry System
2-Propanone, 1,1-dimethoxy- (6342-56-9)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
10-36/38
Safety Statements 
26-36-16
RIDADR 
UN 1224 3/PG 3
WGK Germany 
1
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29145000

MSDS

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Methylglyoxal 1,1-dimethyl acetal Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.

Uses

Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030

Methylglyoxal 1,1-dimethyl acetal Preparation Products And Raw materials

Preparation Products

Raw materials

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