Bromoacetaldehyde dimethyl acetal Chemical Properties

Boiling point:

148-150 °C (lit.)

Density 

1.43 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.445(lit.)

Flash point:

129 °F

storage temp. 

2-8°C

form 

clear liquid

color 

Colorless to Light orange to Yellow

Specific Gravity

1.445

Water Solubility 

insoluble

Sensitive 

Moisture Sensitive

BRN 

1280132

CAS DataBase Reference

7252-83-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 2-bromo-1,1-dimethoxy-(7252-83-7)

EPA Substance Registry System

Ethane, 2-bromo-1,1-dimethoxy- (7252-83-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36-36/37/38

Safety Statements 

26-36/39-28A-16

RIDADR 

UN 1989 3/PG 3

WGK Germany 

3

F 

8-9-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29110000

MSDS

• Language:English Provider:2-Bromo-1,1-dimethoxyethane
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Bromoacetaldehyde dimethyl acetal Usage And Synthesis

Description

2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) is used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization. It is widely used in chemistry for the synthesis of a variety of antibiotics (including erythromycin and cephalosporins) and other drugs. It is an important and highly reactive bifunctional compound with a good leaving group and a masked aldehyde function. It can be used as a starting material in a variety of reactions to provide N-alkylated compounds, lactams, aldehydes, oximes, azides, and acyclic di-/polyselenides.

Reference

Gotkowska, Joanna. "Bromoacetaldehyde Diethyl Acetal." Synlett26.15(2015):2185-2186.

Chemical Properties

clear colourless to light yellow liquid

Uses

2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) was used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization.

Uses

2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) was used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA).

Bromoacetaldehyde dimethyl acetal(7252-83-7)Related Product Information

• Dimethyl sulfoxide
• 2,2-Diethoxyethylamine
• Bromocyclopentane
• Dimethyldimethoxysilane
• Decabromodiphenyl Ethane
• N,N-Dimethylformamide
• Acetal
• beta-Bromostyrene
• Dimethyl ether
• ETHANE
• 3-Bromoanisole
• Methylglyoxal 1,1-dimethyl acetal
• 1-Bromododecane
• 1,2-Dimethoxyethane
• 1,1-Dimethoxyethane
• 2,6-Dimethoxybenzaldehyde
• Dimethoxymethane
• Bromoethane