Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Organic Chemistry >  Organic fluorine compound >  Fluoroaniline series >  2-Bromo-5-fluoroaniline

2-Bromo-5-fluoroaniline

Basic information Safety Supplier Related

2-Bromo-5-fluoroaniline Basic information

Product Name:
2-Bromo-5-fluoroaniline
Synonyms:
  • 2-BROMO-5-FLUOROBENZENAMINE
  • 2-BROMO-5-FLUOROANILINE
  • 2-Bromo-5-fluoro-phenylamine
  • 2-Bromo-5-fluoroaniline 98%
  • 2-Bromo-5-fluoroaniline98%
  • 2-Bromo-5-fluoroaniline,99%
  • 2-Bromo-5-fluoroanil
  • BenzenaMine, 2-broMo-5-fluoro-
CAS:
1003-99-2
MF:
C6H5BrFN
MW:
190.01
Product Categories:
  • amine| alkyl bromide| alkyl Fluorine
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • C6
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Aniline
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Nitrogen Compounds
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Anilines, Amides & Amines
  • Bromine Compounds
  • Fluorine Compounds
  • Pharmaceutical intermediate
  • bc0001
Mol File:
1003-99-2.mol
More
Less

2-Bromo-5-fluoroaniline Chemical Properties

Melting point:
43-47 °C (lit.)
Boiling point:
154 °C / 23mmHg
Density 
1.694±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
1.52±0.10(Predicted)
color 
White to Light yellow to Dark green
InChI
InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey
FWTXFEKVHSFTDQ-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC=C1Br
CAS DataBase Reference
1003-99-2(CAS DataBase Reference)
More
Less

Safety Information

Hazard Codes 
Xi,T
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN2811
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200

MSDS

More
Less

2-Bromo-5-fluoroaniline Usage And Synthesis

Description

2-bromo-5-fluoroaniline: a intermediate of antitumor drug.
2-bromo-5-fluoroaniline is the intermediate of antitumor drug Phortress, phortress is the benzothiazoles CYP1A1 antitumor drugs targeting by Univ Nottingham UK invention, solution becomes lipophilic compound 5F2O3(10 in the sensitive cells but Phortress enters), the latter is as potential aromatic hydrocarbon receptor (AhR) agonist, induce CYP1A1 to express, CYP1A1 metabolism through expressing produces and has high electrophilic active substance again, finally causes DNA damage and apoptosis. The method that, at present, synthetic 2-bromo-5-fluoronitrobenzene prepares 2-bromo-5-fluoroaniline is divided into two large classes:
The one: adopt a chemical reduction method, utilizing the chemical reducing agent reductase 2-bromo-5-fluoronitrobenzenes such as protochloride glass putty, iron powder, vat powder, hydrazine, and sodium borohydride (potassium), which is 2-bromo-5-fluoroaniline.
The 2nd: adopt hydro-reduction. What we do more often both at home and abroad at present is chloride or the catalytic hydrogenation of fluorine-containing arylamine, and the brominated less report of arylamine hydrogenation mainly is easily by hydrogenolysis because of bromine.

Chemical Properties

Yellow to brown crystalline powder

Uses

2-Bromo-5-fluoroaniline may be used to synthesize:

  • orthobromothiobenzanilide of 5-fluoronitrobenzothiazole
  • 2-bromo-5-fluorobenzo[14C]nitrile
  • [3-14C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
  • 2-bromo-5-fluoro-phenyl)-(2-methoxy-6-pentadecyl-benzyl)amine

Synthesis

A preparation method of 2-Bromo-5-fluoroaniline is as follows: methanol, 2-bromo-5-fluoronitrobenzene, W-4 type Raney nickel and bromine inhibitor are put into a hydrogenation kettle to carry out hydrogenation reaction. After the reaction is completed, the reaction solution is filtered under nitrogen protection. The filtered filtrate is then distilled under reduced pressure to remove methanol, and n-hexane is added. Then, the product is washed with process water, and after washing, the product is allowed to stand and separate. Then, the organic phase is cooled and crystallized, an off-white to brownish-yellow solid is precipitated, and a wet product is obtained by suction filtration. The wet product is dried to obtain the finished product 2-Bromo-5-fluoroaniline.

2-Bromo-5-fluoroanilineSupplier

Fuxin Custchem Fine Chemical Co., Ltd. Gold
Tel
0418-5113999 18740177324
Email
sales@custchem.com.cn
ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD Gold
Tel
0571-87322520 18957127338
Email
sales@zetchem.com
China Shenyang Tyschem CO. ,LTD Gold
Tel
+86-024-83607930; 18640359690
Email
sales@honghuchem.com
Fuxin Yinghui High tech Materials Technology Co., Ltd Gold
Tel
17624188899 17624188899
Email
3799130626@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com