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2-Amino-4-phenylbutane

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2-Amino-4-phenylbutane Basic information

Product Name:
2-Amino-4-phenylbutane
Synonyms:
  • .alpha.-Methyl-.gamma.-phenyl-n-propylamine
  • .alpha.-methyl-.gamma.-phenyl-Propylamine
  • (+/-)-AMPHETAMINE
  • DL-AMPHETAMINE
  • AURORA KA-7110
  • α-Methylbenzenepropylamine
  • 2-Amino-4-phenylbutane, 98+%
  • (n)-3-amino-1-phenylbutane
CAS:
22374-89-6
MF:
C10H15N
MW:
149.24
EINECS:
244-942-2
Product Categories:
  • Amines
  • Building Blocks
  • C10
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • AmphetamineStable Isotopes
  • Controlled Drug Standards
  • A
  • Alphabetic
  • AM to AQDrugs of Abuse
  • Chemical Structure
  • 22374-89-6
Mol File:
22374-89-6.mol
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2-Amino-4-phenylbutane Chemical Properties

Melting point:
-50°C
Boiling point:
228-232 °C (lit.)
Density 
0.922 g/mL at 25 °C (lit.)
vapor pressure 
10.146Pa at 25℃
refractive index 
n20/D 1.514(lit.)
Flash point:
208 °F
storage temp. 
−20°C
solubility 
soluble in Chloroform, Ethyl Acetate
form 
liquid
pka
pKa 10.0 (Uncertain)
Specific Gravity
0.922
color 
Clear
PH
11.6 (10g/l, H2O, 20℃)
Water Solubility 
8.5 g/L (20 ºC)
Sensitive 
Air Sensitive
BRN 
2413110
LogP
2.12
CAS DataBase Reference
22374-89-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzenepropanamine, «alpha»-methyl-(22374-89-6)
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Safety Information

Hazard Codes 
C,Xi,T,F
Risk Statements 
34-22-39/23/24/25-23/24/25-11
Safety Statements 
26-36/37/39-45-28A-36/37
RIDADR 
UN 2735 8/PG 3
WGK Germany 
2
RTECS 
UI3920000
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
III
HS Code 
29214980
Toxicity
LD orl-rat: >600 mg/kg AEPPAE 195,647,1940

MSDS

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2-Amino-4-phenylbutane Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

2-Amino-4-phenylbutane is used in the synthesis of N-substituted derivatives of (1-methyl-3- phenylpropyl)amine.

Biological Functions

Amphetamine is an indirectly acting adrenomimetic amine that depends for its action on the release of norepinephrine from noradrenergic nerves. Its pharmacological effects are similar to those of ephedrine; however, its CNS stimulant activity is somewhat greater. Both systolic and diastolic blood pressures are increased by oral dosing with amphetamine. The heart rate is frequently slowed reflexively. Cardiac output may remain unchanged in the low- and moderate-dose range. The therapeutic uses of amphetamine are based on its ability to stimulate the CNS. The D-isomer (dextroamphetamine) is three to four times as potent as the L-isomer in producing CNS effects. It has been used in the treatment of obesity because of its anorexic effect, although tolerance to this effect develops rapidly. It prevents or overcomes fatigue and has been used as a CNS stimulant. Amphetamine is no longer recommended for these uses because of its potential for abuse. Amphetamine is useful in certain cases of narcolepsy or minimal brain dysfunction.

Flammability and Explosibility

Not classified

Safety Profile

A poison by intraperitoneal and parenteral route. Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors of NOx.

Synthesis

Amphetamine is prepared by treating phenylacetone with formic acid and ammonia under the Leuckart-Wallach conditions .

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