ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE Chemical Properties

Boiling point:

80 °C

CAS DataBase Reference

175278-02-1

Safety Information

Risk Statements 

20/21/22

Safety Statements 

23-36/37/39

HS Code 

2916399090

ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE Usage And Synthesis

Synthesis

A mixture of 3,5-bis(trifluoromethyl)bromobenzene (0.5 mmol) and potassium monoethyl malonate (0.75 mmol) was added to a 30 mL microwaveable tubular flask with THF (10 mL) with stirring, followed by Pd(OAc)2 (5 mol%), Xantphos (5 mol%), MgCl2 (0.75), Et3N (0.75), imidazole (1 mmol). mmol), imidazole (1 mmol), then Co2(CO)8 (0.15 mmol) was added and the tubular vial was immediately sealed and microwaved at 90??C for 30 min. The mixture was diluted with ethyl acetate and water. The ethyl acetate layer was separated, dried with sodium sulfate and concentrated. The crude product obtained was purified by column chromatography and the pure compound was obtained using 0 to 5% hexane solution of ethyl acetate.

ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE(175278-02-1)Related Product Information

• 3-(3-Trifluoromethylphenyl)propionic acid
• 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
• 3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL
• 3'-(Trifluoromethyl)acetophenone
• 3-(Trifluoromethyl)benzaldehyde
• 3-OXO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
• 3',5'-BIS(TRIFLUOROMETHYL)PROPIOPHENONE
• 3',5'-Bis(trifluoromethyl)acetophenone
• METHYL 3-(TRIFLUOROMETHYL)BENZOYLACETATE
• 3-(3-METHYLPHENYL)PROPIONIC ACID
• 3,5-Bis(trifluoromethyl)benzaldehyde
• ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE
• 3'-(TRIFLUOROMETHYL)PROPIOPHENONE
• Ethyl benzoylacetate
• 1,3-Bis(trifluoromethyl)-benzene
• 3,5-BIS(TRIFLUOROMETHYL)TOLUENE
• 3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
• 3-(3-METHYLPHENYL)PROPIONALDEHYDE