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D-CAMPHOR

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D-CAMPHOR Basic information

Product Name:
D-CAMPHOR
Synonyms:
  • 7,7-trimethyl-(1r)-bicyclo(2.2.1)heptan-2-on
  • 7,7-trimethyl-(1theta)-bicyclo[2.2.1]heptan-2-on
  • Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-
  • R-(+)-Camphor
  • D-(+)-Camphor,98%
  • CAMPHOR FLAKE, USP24
  • CAMPHOR, (+)-(SG)
  • (1R,4R)-(+)-Camphor
CAS:
464-49-3
MF:
C10H16O
MW:
152.23
EINECS:
207-355-2
Product Categories:
  • Inhibitors
  • Alphabetical Listings
  • Bicyclic Monoterpenes
  • Biochemistry
  • C-D
  • Flavors and Fragrances
  • Food and Feed Additive
  • Camphor, etc. (Plasticizer)
  • Functional Materials
  • Plasticizer
  • Terpenes
Mol File:
464-49-3.mol
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D-CAMPHOR Chemical Properties

Melting point:
178-182 °C (lit.)
Boiling point:
204 °C
alpha 
D25 +41 to +43° (c = 10 in U.S.P. alcohol) according to U.S.P. specif
Density 
0,99 g/cm3
vapor density 
5.24 (vs air)
vapor pressure 
4 mm Hg ( 70 °C)
FEMA 
2230 | D-CAMPHOR
refractive index 
44.5 ° (C=20, EtOH)
Flash point:
148 °F
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very soluble in alcohol and in light petroleum, freely soluble in fatty oils, very slightly soluble in glycerol.
form 
Crystals
color 
White
Odor
at 10.00 % in dipropylene glycol. camphor minty phenolic herbal woody
Odor Type
camphoreous
explosive limit
3.5%
optical activity
[α]25/D +44°, c = 10 in ethanol
Water Solubility 
Soluble in water (0.1 g/L at 20°C).
Merck 
14,1732
JECFA Number
1395
BRN 
2042745
Stability:
Stable. Incompatible with strong reducing agents, strong oxidizing agents, chlorinated solvents. Protect from direct sunlight.
LogP
2.3 at 20℃
CAS DataBase Reference
464-49-3(CAS DataBase Reference)
EPA Substance Registry System
D-Camphor (464-49-3)
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Safety Information

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-22-36/37/38-20/21/22-36
Safety Statements 
16-26-36-37/39
RIDADR 
UN 2717 4.1/PG 3
WGK Germany 
1
RTECS 
EX1260000
Autoignition Temperature
870 °F
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29142910

MSDS

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D-CAMPHOR Usage And Synthesis

Description

(1R)-(+)-Camphor is a terpene that has been found in C. sativa, C. indica, and C. sativa/C. indica hybrid strains as well as the essential oils from a variety of herbs including rosemary, lavender, and sage and has diverse biological activities. It inhibits norepinephrine secretion and cytosolic calcium and sodium increases induced by the nicotinic acetylcholine receptor (nAChR) agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) in chromaffin cells (IC50s = 70, 88, and 19 μM, respectively). (1R)-(+)-Camphor (65-260 μM) induces proliferation of and increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts. In vivo, (1R)-(+)-camphor increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in skin in UV-exposed mice when administered at doses of 26 and 55 mM in drinking water post UV-exposure. It reduces cough frequency in citric acid-challenged guinea pigs. (1R)-(+)-Camphor is insecticidal, reducing digging activity and inducing mortality of fire ant workers. It has also been used as a building block in the synthesis of cannabinergic ligands.

Chemical Properties

white crystals

Chemical Properties

d-Camphor has a warm, minty, almost ethereal diffusive aroma. For other details of description, see Camphor Tree.

Occurrence

Frequently occurring in nature as the d- or l-form; the optically inactive form is seldom encountered. The d-form has been reported found in Cinnamomum camphora Ness. (Laurus camphora L.) from China, Japan and the East Indies; in Sassafras officinale, Lavandula spica and in other Labiatae. The l-form is reported found in the essential oils of Salvia grandiflora, Matricaria parthenium, Artemisia herba alba; the optically inactive form is found in Chrysanthemum japonicum sinense. Also reported found in orange peel oil, lemon peel oil, apricot, raspberry, anise, cinnamon root bark, ginger, pepper, coriander, calamus, sweet fennel and rosemary.

Uses

(1R)-(+)-Camphor is used as a chiral intermediate and auxiliary. It is also used as a skin antipruritic and as an anti-infective agent.

Uses

analgesic, antiinfective, antipruritic

Uses

D-Camphor may be used as reference material for the quantification of the analyte in Saraca asoca and coriander using chromatography techniques.

Uses

(R)-(+)-Camphor is a terpenoid with a wide variety of use. (R)-(+)-Camphor has insecticidal activity and is also used as an antimicrobial agent. (R)-(+)-Camphor is used as a culinary flavouring agent in parts of asia.

Definition

ChEBI: The (R)- enantiomer of camphor.

Aroma threshold values

Detection at 1 to 1.29 ppm

Taste threshold values

Taste characteristics at 20 ppm: medicinal, camphoraceous, mentholic and woody.

General Description

Colorless or white crystals. Sublimes. Flash point 149°F. Burns readily with a bright, smoky flame. Penetrating aromatic odor. Pungent, aromatic taste followed by a sensation of cold.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

D-CAMPHOR is incompatible with strong oxidizing agents, strong reducing agents and chlorinated solvents.

Fire Hazard

D-CAMPHOR is combustible.

Flammability and Explosibility

Flammable

Synthesis

Natural camphor is obtained by distillation from the plants of Cinnamomum or Laurus camphora from China and Japan, together with the corresponding essential oils; the raw camphor contains several impurities. It is separated from the water and the essential oil by pressure or by centrifugation and subsequently purified by sublimation or crystallization. Synthetic camphor is prepared from pinene isolated by fractional distillation of turpentine oil; pinene is reacted to bornyl chloride with gaseous HCl under pressure and then to camphene. The distilled and purified camphene is then oxidized to camphor with Na+ or K+ bichromate in the presence of H2SO4.

Purification Methods

Crystallise it from EtOH, 50% EtOH/water, MeOH, or pet ether or from glacial acetic acid by addition of water. It can be sublimed (50o/14mm) and also fractionally crystallised from its own melt. It is steam volatile. It should be stored in tight containers as it is appreciably volatile at room temperature. The solubility is 0.1% (H2O), 100% (EtOH), 173% (Et2O) and 300%

D-CAMPHOR Preparation Products And Raw materials

Preparation Products

D-CAMPHORSupplier

Jiangxi Xuesong Natural Medicinal Oil Co. LTD Gold
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18679669723 18679669723
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Jinan Wald Chemical Co., Ltd. Gold
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0531-88773586 13210588999
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Jiangxi yuanshangcao flavor Co., Ltd. Gold
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0796-828-2352 18979604038
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Jiangxi Planty Manor Health Industry Co., Ltd. Gold
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0796-18507969315 18507969315
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Sigma-Aldrich Gold
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021-61415566 800-8193336
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