TRIS(2-AMINOETHYL)AMINE Chemical Properties

Melting point:

-16 °C

Boiling point:

114 °C/15 mmHg (lit.)

Density 

0.976 g/mL at 20 °C (lit.)

vapor density 

5 (vs air)

vapor pressure 

0.02 mm Hg ( 20 °C)

refractive index 

n20/D 1.497(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), DMSO (Slightly)

form 

saline suspension

pka

10.00±0.10(Predicted)

color 

Clear yellow

Specific Gravity

0.977

Water Solubility 

Miscible with water.

Sensitive 

Hygroscopic

BRN 

1739626

Stability:

Stable. Hygroscopic. Absorbs carbon dioxide from the air. Incompatible with strong acids, strong oxidizing agents.

CAS DataBase Reference

4097-89-6(CAS DataBase Reference)

EPA Substance Registry System

1,2-Ethanediamine, N,N-bis(2-aminoethyl)- (4097-89-6)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

22-24-34-36/37/38-10

Safety Statements 

26-36/37/39-45-16

RIDADR 

UN 2922 8/PG 2

WGK Germany 

3

RTECS 

KH8587082

F 

3-10-23

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29211990

Toxicity

mouse,LD50,oral,1800mg/kg (1800mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSIONBEHAVIORAL: ATAXIAGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA","Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 223, 1999.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TRIS(2-AMINOETHYL)AMINE Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Tris(2-aminoethyl)amine is a tetradentate chelating ligand and forms stable complexes with transition metals. It is also used as a carbon dioxide absorbent. Further, it acts as a reagent for cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group in peptide synthesis. It reacts with aryl isocyanates and isothiocyanates to give tris-urea and -thiourea derivatives.

Definition

ChEBI: Tris(2-aminoethyl)amine is a tetramine.

General Description

Tris(2-aminoethyl)amine (TREN) is a water soluble tripodal ligand that is majorly used in co-ordination chemistry. It has three aminoethylgroups that attach with the surface atoms to provide a scaffold assembly.

Hazard

A poison by ingestion and skin contact.

Safety Profile

A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]

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