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2-Methyl-D-phenylalanine

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2-Methyl-D-phenylalanine Basic information

Product Name:
2-Methyl-D-phenylalanine
Synonyms:
  • N-ME-D-PHENYLALANINE
  • N-ME-D-PHE-OH
  • N-METHYL-D-PHENYLALANINE
  • (R)-2-METHYLPHENYLALANINE
  • (R)-2-AMINO-2-METHYL-3-PHENYLPROPANOIC ACID
  • (R)-2-AMINO-2-METHYL-3-PHENYLPROPIONIC ACID
  • N-ALPHA-METHYL-D-PHENYLALANINE
  • ALPHA-BENZYL-D-ALA
CAS:
17350-84-4
MF:
C10H13NO2
MW:
179.22
Product Categories:
  • α-Methyl Amino Acids
  • unnatural amino acids
  • Unusual amino acids
  • pharmacetical
  • Chiral Reagent
Mol File:
17350-84-4.mol
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2-Methyl-D-phenylalanine Chemical Properties

Melting point:
277-279 °C(Solv: acetone (67-64-1))
Boiling point:
312.8±30.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
Powder
pka
2.25±0.10(Predicted)
color 
White to pale yellow
BRN 
5254151
CAS DataBase Reference
17350-84-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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2-Methyl-D-phenylalanine Usage And Synthesis

Chemical Properties

White powder

Uses

α-Methyl-D-phenylalanine is used to prepare hippuryl-α-methylphenylalanine and hippuryl-α-methylphenyllactic acid as substrates for carboxypeptidase A. It is also used in the synthesis of high affinity tachykinin NK2 receptor antagonists.

Uses

2-Methyl-D-phenylalanine is a derivative of D-Phenylalanine (P319410); the stereoisomer of L-Phenylalanine (P319415) used in the synthesis of Schaeffer’s acid analogs as important structures in tuberculostatic design. These analogs exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.

reaction suitability

reaction type: solution phase peptide synthesis

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