DL-METHIONINE METHYLSULFONIUM CHLORIDE Chemical Properties

Melting point:

139-140 °C (dec.)

FEMA 

3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H2O: soluble100mg/mL, clear, colorless

form 

Solid

color 

White to Off-White

PH

4.0-5.5

Water Solubility 

Water: 250 mg/mL (1251.88 mM)

JECFA Number

1427

Merck 

14,6098

BRN 

4163617

Stability:

Hygroscopic

InChIKey

MYGVPKMVGSXPCQ-UHFFFAOYSA-N

CAS DataBase Reference

3493-12-7(CAS DataBase Reference)

EPA Substance Registry System

Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride (3493-12-7)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29309090

DL-METHIONINE METHYLSULFONIUM CHLORIDE Usage And Synthesis

Description

DL-Methionine methylsulfonium chloride, also named Vitamin U, is a powerful antioxidant. It is a sulfur derivative substance. Graviola leaves contain much vitamin U[1]. Vitamin U have unique antioxidant effect. It could prevents Galactosamine-induced gastric damage and protects pentylenetetrazole-induced brain damage in rats[2-3].

Uses

DL-Methionine Methylsulfonium Chloride is a compound comprised of γ-glutamyl peptide and amino acid that have a sucrose-like taste.

Uses

Vitamin U (DL-methionine methylsulfonium chloride) is a natural methionine-derivative, found as an active component in the methionine cycle of plants where it serves as a substrate for methyl transferases (Augspurger et al., 2005). Historically this compound has been utilized as either a cure or preventative against gastric and duodenal ulcers (Nakamura et al., 1981).

Biochem/physiol Actions

S-Methionine methylsulfonium (SMMS) chloride is a derivative of methionine metabolism in some plants. SMMS has potent therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth.

References

[1] Choi E, et al. Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification. Nutrients, 2019; 11.
[2] Topaloglu D, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of Biochemical and Molecular Toxicology, 2022; 36: e23124.
[3] Bayrak G, et al. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats, 2022; 36: e23169.

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