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2',4'-Dihydroxy-3',6'-dimethoxychalcone

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2',4'-Dihydroxy-3',6'-dimethoxychalcone Basic information

Product Name:
2',4'-Dihydroxy-3',6'-dimethoxychalcone
Synonyms:
  • 1-(2,4-Dihydroxy-3,6-diMethoxyphenyl)-3-phenylprop-2-en-1-one
  • 2',4'-DIHYDROXY-3',6'-DIMETHOXYC
  • 2-Propen-1-one, 1-(2,4-dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-, (2E)-
  • 4'-Dihydroxy-3'
  • 6'-dimethoxychalcone
  • (2E)-1-(2,4-Dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
CAS:
129724-43-2
MF:
C17H16O5
MW:
300.31
Mol File:
129724-43-2.mol
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2',4'-Dihydroxy-3',6'-dimethoxychalcone Usage And Synthesis

Uses

2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC50 values of 10.67 and 18.60 μM, respectively[1][2].

References

[1] Ahmed M, et al. Isoflavan-4-ol, dihydrochalcone and chalcone derivatives from Polygonum Lapathifolium. Phytochemistry, 1990, 29(6):2009-2011.
[2] Nkuété AH, et al. Anti-leukemia activity of semi-synthetic phenolic derivatives from Polygonum limbatum Meisn. Chem Cent J. 2015 Jun 24;9:40. DOI:10.1186/s13065-015-0115-2

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