Basic information Safety Supplier Related

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-

Basic information Safety Supplier Related

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Basic information

Product Name:
Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-
Synonyms:
  • Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-
  • (1S,2R)-BortezoMib
  • (S)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butylboronic acid
  • N-(2-Pyrazinecarbonyl)-D-phenylalanine-D-leucine boronic anhydride
  • Bortezomib Impurity (1S,2R - Isomer)
  • Bortezomib impurity 2/(1S,2R)-Bortezomib
  • Bortezomib (1R,2R)Isomer
  • (1S,2R)-Bortezomib Impurity
CAS:
1132709-16-0
MF:
C19H25BN4O4
MW:
384.24
Product Categories:
  • Chiral Reagents, Boron Derivatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
1132709-16-0.mol
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Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Chemical Properties

Density 
1.214±0.06 g/cm3(Predicted)
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
9.66±0.43(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic, Light sensitive, Moisture sensitive
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Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- Usage And Synthesis

Uses

(1S,3R)-Bortezomib is an diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway

Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-Supplier

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