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ANDROGRAPHOLIDE, DEOXY-

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ANDROGRAPHOLIDE, DEOXY- Basic information

Product Name:
ANDROGRAPHOLIDE, DEOXY-
Synonyms:
  • ANDROGRAPHOLIDE, DEOXY-
  • DEOXYANDROGRAPHOLIDE
  • 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one
  • 2(5H)-Furanone, 3-[2-[(4aS,5R,6R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]ethyl]-
  • 3-[2-[(4aS,5R,6R,8aR)-3,4,4a,5,6,7,8,8a-Octahydro-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]ethyl]-2(5H)-furanone
  • 3-(2-((4aS,5R,6R,8aR)-6-Hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
CAS:
79233-15-1
MF:
C20H30O4
MW:
334.45
EINECS:
2017-001-1
Mol File:
79233-15-1.mol
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ANDROGRAPHOLIDE, DEOXY- Chemical Properties

Boiling point:
511.7±50.0 °C(Predicted)
Density 
1.123±0.06 g/cm3(Predicted)
pka
14.89±0.70(Predicted)
form 
Solid
color 
White to off-white
CAS DataBase Reference
79233-15-1
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ANDROGRAPHOLIDE, DEOXY- Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Andrographis paniculata (Burm. f.) Nees.

Uses

Deoxyandrographolide has antipyretic, anti-inflammatory, anti-leptin properties. Treponema pallidosis, antibacterial, anticancer, hepatoprotective and antihypertensive activities.

Biological Activity

Deoxyandrographolide, isolated from Andrographis paniculata, inhibits LPS-induced elevation of iNOS mRNA levels and production of pro-inflammatory mediators TNF-α and IL-6. It enhances NGF-induced neurite outgrowth.

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