- Product Name:
- Beta-propiolactone, 98%, pure
- Propiolactone research grade
- β-Propiolactone ,98%
- BETA-PROPIOLACTONERESEARCH GRADE
- β-Propiolactone,3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone
- b-Propiolactone, Reagent
- beta-Hydroxypropionic Acid Lactone 2-Oxetanone beta-Propionolactone
- BETA-HYDROXYPROPIONIC ACID LACTONE
- Product Categories:
- Building Blocks
- Carbonyl Compounds
- Chemical Synthesis
- Organic Building Blocks
- Intermediates & Fine Chemicals
- Miscellaneous Reagents
- Mol File:
2-Oxetanone Chemical Properties
- Melting point:
- -33 °C (lit.)
- Boiling point:
- 162 °C (lit.)
- 1.146 g/mL at 25 °C (lit.)
- vapor pressure
- 3 at 25 °C (NIOSH, 1997)
- refractive index
- n20/D 1.412(lit.)
- Flash point:
- 158 °F
- storage temp.
- Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
- Colorless liquid with a sweet but irritating odor
- Water Solubility
- 37 g/100 mL
- Moisture Sensitive
- Henry's Law Constant
- 7.6 at 25 °C (approximate - calculated from water solubility and vapor pressure)
- CAS DataBase Reference
- 57-57-8(CAS DataBase Reference)
- 2B (Vol. 4, Sup 7, 71) 1999
- NIST Chemistry Reference
- EPA Substance Registry System
- beta-Propiolactone (57-57-8)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 3382 6.1/PG 1
- WGK Germany
- HS Code
- Hazardous Substances Data
- 57-57-8(Hazardous Substances Data)
- LC50 (inhalation) for rats 25 ppm/6-h (quoted, RTECS, 1985).
2-Oxetanone Usage And Synthesis
Beta-propiolactone is a colorless liquid with a strong, slightly
sweet odor. It may occur naturally, but no clear documentation
of its occurrence in nature was found, and it must be synthesized
for commercial purposes. Beta-propiolactone is unstable
at room temperature but stable when stored at 5 C in glass
Its tendency to be unstable and react with other molecules in the vicinity is responsible for both its toxicity and its usefulness. Significant commercial production of beta-propiolactone took place during the late 1950s through the mid-1970s, when it was widely used in chemical synthesis in reactions with other molecules to produce new chemicals. All lactones are characterized by a ring structure consisting of two or more carbon atoms – as can be seen from its structure, beta-propiolactone has three in its ring – and a single oxygen, coupled with an adjacent ketone. The fewer the carbons in the ring, the more ‘strained’ is the ring structure and the more unstable and reactive its characteristics. When the ring bonds break, the betapropiolactone molecules attach to other nearby molecules.
β-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable.
Colorless to light yellow liqui
Reacts with bacteriphage DNA causing inactivation, repair and recombination
Versatile intermediate in organic synthesis.
A colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.
Air & Water Reactions
Slow reaction with water to form beta- hydroxypropionic acid.
2-Oxetanone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. 2-Oxetanone may be incompatible with alkalis.
Strong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.
The toxicity potential of 2-Oxetanone via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.
Containers may explode. When heated to decomposition, 2-Oxetanone emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
β-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.
β-Propiolactone is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Chemical/Physical. Slowly hydrolyzes to hydracrylic acid (Windholz et al., 1983). In a reactor heated to 250 °C and a pressure of 12 mmHg, β-propiolactone decomposed to give equal amounts of ethylene and carbon dioxide (James and Wellington, 1969).
UN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Fractionally distil the lactone from sodium under reduced pressure. It gives an acidic solution in H2O. It irritates the skin and is a possib
It is soluble in water (370 g l1 at 25°C) and miscible in other common organic solvents including acetone, chloroform, diethyl ether, and ethanol (Log Kow 0.462). Hydrolysis occurs in water where the half-life in aqueous media at 25°C is approximately 3.5 h. If released to soil, relatively rapid hydrolysis can be expected to occur in the presence of moisture. Significant evaporation may occur from dry surfaces. With a vapor pressure of 3.4 mm Hg at 25°C, it can also vaporize into the air as temperature rises. If released to the atmosphere, beta-propiolactone is expected to exist in the gas phase, where it may be relatively more persistent in the absence of moisture than it is in aqueous media. The half-life for the reaction with photochemically produced hydroxyl radicals was estimated to be a relatively slow rate of 45 days in the atmosphere.
Reacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Oxetanone Preparation Products And Raw materials
- 010-82848833- ;010-82848833-
- ALPHA-ACETAMINOCINNAMIC LACTONE
- N-CARBOBENZOXY-L-SERINE BETA-LACTONE
- (S)-4-(TRICHLOROMETHYL)-2-OXETANONE,(S)-4-(TRICHLOROMETHYL)-2-OXETANONE PURISS. 99+%
- (S)-3-AMINO-2-OXETANONE P-TOLUENESULFONIC ACID SALT
- (2-OXO-OXETAN-3-YL)-CARBAMIC ACID BENZYL ESTER
- Folic acid
- Citric acid
- Hyaluronic acid
- Ascoric Acid