3,5-Difluorophenol Chemical Properties

Melting point:

54-57 °C (lit.)

Boiling point:

65-68°C 1mm

Density 

1.2483 (estimate)

Flash point:

159 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

ethanol: soluble50, clear, colorless to faint yellow or tan (mg/mL)

pka

7.97±0.10(Predicted)

form 

Crystals

color 

White to beige

BRN 

2078616

InChI

InChI=1S/C6H4F2O/c7-4-1-5(8)3-6(9)2-4/h1-3,9H

InChIKey

HJSSBIMVTMYKPD-UHFFFAOYSA-N

SMILES

C1(O)=CC(F)=CC(F)=C1

CAS DataBase Reference

2713-34-0(CAS DataBase Reference)

NIST Chemistry Reference

3,5-Difluorophenol(2713-34-0)

Safety Information

Hazard Codes 

Xn,Xi,C,F

Risk Statements 

20/21/22-36/37/38-34-11

Safety Statements 

26-36-45-36/37/39-16

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

6.1

PackingGroup 

III

HS Code 

29081000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Difluorophenol Usage And Synthesis

Chemical Properties

white to beige crystals

Uses

3,5-Difluorophenol is an important medicine, pesticide, and liquid crystal material intermediate, mainly used in the synthesis of liquid crystal materials and antifungal agents, and also used in the synthesis of dyes, plastics and rubber additives.

Synthesis

The general procedure for the synthesis of 3,5-difluorophenol from 3,5-difluorobromobenzene was as follows: referring to the method described in Example 1, the feedstock was replaced with 96.5 g (0.5 mol) of 3,5-difluoro-1-bromobenzene, and Raney Ni was used as a catalyst. The reaction temperature was raised to 130 °C and pressurized to 0.8 MPa under nitrogen atmosphere. keeping the rest of the reaction conditions unchanged, 52.6 g of 3,5-difluorophenol was finally obtained, with a melting point of 39-41 °C, a yield of 80.8%, and a product purity of 99.65%.

References

[1] Patent: CN105384603, 2016, A. Location in patent: Paragraph 0030

3,5-Difluorophenol(2713-34-0)Related Product Information

• 2,6-Dimethylphenol
• 4-Fluorophenol
• Xylenol
• 2,4-DIFLUOROPHENOL,2,4-Difluorophenol, 98+%,2,4-Difluorophenol, 99+%
• 2,6-DIFLUOROPHENOL
• 3,4-Difluorophenol,98%,3,4-DIFLUOROPHENOL
• 2,3-Difluorophenol,98+%,2,3-DIFLUOROPHENOL
• 2,5-DINITROPHENOL
• FMOC-GLY-OPFP
• FMOC-ASP(OTBU)-OPFP
• 3,4,5-Trifluorophenol
• 9-FLUORENYLMETHYL PENTAFLUOROPHENYL CARBONATE
• 2,3,4,5,6-PENTAFLUOROANISOLE
• PENTAFLUOROPHENOXYACETIC ACID
• 2,3,5,6-Tetrafluorophenol
• PENTAFLUOROPHENYL METHACRYLATE
• 2,3,5,6-TETRAFLUOROANISOLE
• Tetrafluorohydroquinone