2,4-Difluorophenol Chemical Properties

Melting point:

22.4 °C (lit.)

Boiling point:

52-53 °C/19 mmHg (lit.)

Density 

1.362 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.486(lit.)

Flash point:

134 °F

storage temp. 

Inert atmosphere,Room Temperature

pka

8.72±0.18(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Yellow

Specific Gravity

1.362

Water Solubility 

slightly soluble

BRN 

1934803

InChIKey

NVWVWEWVLBKPSM-UHFFFAOYSA-N

CAS DataBase Reference

367-27-1(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Difluorophenol(367-27-1)

Safety Information

Hazard Codes 

Xn,Xi,C,F

Risk Statements 

20/21/22-37/38-41-34-11-36/37/38

Safety Statements 

26-36/37/39-45-16

RIDADR 

1992

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

3

PackingGroup 

III

HS Code 

29081000

MSDS

• Language:English Provider:2,4-Difluorophenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Difluorophenol Usage And Synthesis

Chemical Properties

clear yellow-green liquid after melting

Uses

2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria.

Uses

2,4-Difluorophenol has been used:

• as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine
• in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye

2,4-Difluorophenol(367-27-1)Related Product Information

• 4-Fluorophenol
• 2,6-Dimethylphenol
• Xylenol
• 2,5-DINITROPHENOL
• 3,4-DIFLUOROPHENOL
• 2,3-Difluorophenol,98+%,2,3-DIFLUOROPHENOL
• Pentafluorophenol
• PENTAFLUOROPHENYL ACRYLATE
• Benzene, 1,2,3-trifluoro-4-methoxy- (9CI)
• FMOC-ASP(OTBU)-OPFP
• 2,4,6-Trifluorophenol
• PENTAFLUOROPHENOXYACETIC ACID
• PENTAFLUOROPHENYL METHACRYLATE
• 2,3,4-TRIFLUOROPHENOL
• 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
• 9-FLUORENYLMETHYL PENTAFLUOROPHENYL CARBONATE
• 2,3,4,5,6-PENTAFLUOROANISOLE
• FMOC-GLY-OPFP