3-METHYL-1H-INDAZOLE Chemical Properties

Melting point:

113°C

Boiling point:

234.08°C (rough estimate)

Density 

1.1083 (rough estimate)

refractive index 

1.6013 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

14.39±0.40(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933998090

3-METHYL-1H-INDAZOLE Usage And Synthesis

Description

3-Methyl-1H-indazole is a heterocyclic alkyl compound containing nitrogen and three methyl groups. It is used as an intermediate in the synthesis of other compounds. It has been shown to have anti-inflammatory properties in vitro. It also inhibits neutrophil chemotaxis and may be used to treat inflammatory diseases such as trigeminal neuralgia or heart disease. 3-Methyl-1H-indazole has also been shown to inhibit histamine H3 receptor activity, which may account for its effects on eye diseases and bladder cancer.

Uses

3-Methyl-1H-indazole is an intermediate compound. It can be used as an organic synthesis reagent for the preparation of 3-methyl-1H-indazol-5-amine and 3-methyl-5-nitro-1H-indazole compounds. In addition, the 3-Methyl-1H-indazole derivatives (1a-1d and 2a-2d) have antimicrobial effects, both having antibacterial activity against Bacillus subtilis and Escherichia coli^[1].

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 1817, 1988 DOI: 10.1002/jhet.5570250641
Synthesis, p. 982, 1984

References

[1] FARRUKH SHAIKH. Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives[J]. Intelligent Pharmacy, 2024. DOI:10.1016/j.ipha.2023.09.003.

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