4-Isopropylphenol Chemical Properties

Melting point:

59-61 °C (lit.)

Boiling point:

212-213 °C (lit.)

Density 

0.9900

vapor density 

>1 (vs air)

refractive index 

1.5228

Flash point:

108°C

storage temp. 

Store at +2°C to +8°C.

solubility 

Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)

pka

10.19±0.13(Predicted)

form 

Crystalline Mass or Crystals

color 

White to beige-brown

Odor

at 1.00 % in dipropylene glycol. woody warm spicy medicinal

Odor Type

woody

Water Solubility 

Slightly soluble in water, soluble in ethanol and ethyl ether.

BRN 

1363564

Cosmetics Ingredients Functions

PERFUMING

LogP

2.900

CAS DataBase Reference

99-89-8(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 4-(1-methylethyl)-(99-89-8)

EPA Substance Registry System

p-Isopropylphenol (99-89-8)

Safety Information

Hazard Codes 

C

Risk Statements 

22-34-43-52/53

Safety Statements 

26-36/37/39-45-61

RIDADR 

UN 2430 8/PG 3

WGK Germany 

2

RTECS 

SL5950000

Hazard Note 

Corrosive/Harmful

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

III

HS Code 

29071900

MSDS

• Language:English Provider:p-Cumenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Isopropylphenol Usage And Synthesis

Chemical Properties

WHITE TO BEIGE CRYSTALLINE SOLID

Uses

4-Isopropylphenol was used in the synthesis of vinyl compounds. It is used as a flavor & fragrance agent in cosmetics.

Uses

4-Isopropylphenol is an Impurity of Propofol (P829750).

Production Methods

4-Isopropylphenol is produced:
1) by isolation from Eucalyptus polybractea oil.
2) from Magnesium para-iso-propylphenyl-bromide by air oxidation.

Definition

ChEBI: 4-isopropylphenol is a member of the class of phenols that is phenol which is carrying an isopropyl group at position 4. It has a role as a flavouring agent. It derives from a hydride of a cumene.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3889, 1949 DOI: 10.1021/ja01180a005
Synthesis, p. 396, 1978 DOI: 10.1055/s-1978-24762

General Description

Sonochemical degradation of 4-Isopropylphenol has been studied.

4-Isopropylphenol(99-89-8)Related Product Information

• M-ISOPROPYLPHENOL,Isopropylphenol, meta,3-ISOPROPYLPHENOL,3-ISOPROPYLPHENOL 97+%,3-ISOPROPYLPHENOL 98%,3-ISOPROPYLPHENOL 98+%,META-ISOPROPYLPHENOL
• 2,4-DIISOPROPYLPHENOL
• Propofol
• Phenol
• 2-Isopropoxyphenol
• 4-Isopropylbenzoic acid
• Lithium diisopropylamide
• N,N-Diisopropylethylamine
• Cuminaldehyde
• Cumene
• Diisopropylamine
• Chloromethyl isopropyl carbonate
• 4-ISOPROPYLBENZENESULFONYL CHLORIDE
• 4'-Isopropylacetophenone
• 4-Isopropylaniline
• O-ISOPROPYLPHENOL,2-ISOPROPYLPHENOL 98+%,Isopropylphenol, ortho,2-ISOPROPYLPHENOL
• 3,6-Diisopropyl-1,2-benzenediol
• 2,6-Diisopropyl-1,4-benzoquinone