2-Morpholinoethyl isocyanide Chemical Properties

Boiling point:

72-73 °C0.7 mm Hg(lit.)

Density 

1.017 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.469

Flash point:

110 ºC

storage temp. 

-20°C

form 

liquid

BRN 

4666990

CAS DataBase Reference

78375-48-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-36/37/38

Safety Statements 

26-36/37-45

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

F 

10-21

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

2-Morpholinoethyl isocyanide Usage And Synthesis

Uses

2-Morpholinoethyl isocyanide can be used for the synthesis of:

• Nitrogen acyclic carbene (NAC) complexes to be used as catalysts for the synthesis of phenol and hydration of alkynes.
• Variety of imidazo[1,2-a]pyridines and α-acylaminoamides by Ugi condensation reaction.
• 2-Aminobenzoxazoles and 3-aminobenzoxazines having important therapeutic activities.

Synthesis

2-Morpholinoethyl isocyanide is prepared by the reaction of 2-morpholinoethylamine with Formic Acid in boiling toluene with a water separator, to yield the formamide which is treated either with Phosgene and Triethylamine in CH2Cl2 or with Phosphorus Oxychloride and Diisopropylamine. The use of diisopropylamine as base is favored as yields are improved, typically to 68%. Trichloroacetic Anhydride has also been used as an alternative for COCl2, giving a yield of 74%.

2-Morpholinoethyl isocyanide(78375-48-1)Related Product Information

• ALLYL ISOCYANATE
• Chlorosulfonyl isocyanate
• Propyl isocyanate
• 4-Fluorophenyl isocyanate
• tert-Butylisocyanate
• 1,3,5-Tri-2-propenyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
• Ethyl isocyanate
• Isocyanic acid 3,4-dichlorophenyl ester
• Phenethyl isocyanate
• METHYLIDYNETRI-P-PHENYLENE TRIISOCYANATE
• METHYL ISOCYANATE
• Phenyl isocyanate
• morpholine
• 4-(2-Aminoethyl)morpholine
• METHYL ISOCYANIDE
• ETHYL ISOCYANIDE
• N-MORPHOLINO-2-ISOCYANO-ACETAMIDE
• 2-Morpholinoethyl isocyanide