Basic information Safety Supplier Related

4-(2-Aminoethyl)morpholine

Basic information Safety Supplier Related

4-(2-Aminoethyl)morpholine Basic information

Product Name:
4-(2-Aminoethyl)morpholine
Synonyms:
  • LABOTEST-BB LT02100621
  • 4-(2-AMINOETHYL)MORPHOLINE
  • 4-MORPHOLINEETHANAMINE
  • 2-MORPHOLINOETHYLAMINE
  • 2-MORPHOLIN-4-YL-ETHYLAMINE
  • 2-(4-MORPHOLINO)ETHYLAMINE
  • 4-Morpholineethaneamine
  • 2-(4-MORPHOLINO)ETHYLAMINE 97%
CAS:
2038-03-1
MF:
C6H14N2O
MW:
130.19
EINECS:
218-011-6
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Building Blocks
  • Heterocyclic Building Blocks
  • Heterocyclic Building Blocks
  • Morpholines/Thiomorpholines
  • Morpholines
Mol File:
2038-03-1.mol
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4-(2-Aminoethyl)morpholine Chemical Properties

Melting point:
24 °C
Boiling point:
205 °C(lit.)
Density 
0.992 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.476(lit.)
Flash point:
347 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Chloroform, Methanol
form 
Liquid After Melting
pka
pK1: 4.06(+2);pK2: 9.15(+1) (25°C)
color 
Clear colorless to pale yellow
Water Solubility 
soluble
Sensitive 
Air Sensitive
BRN 
104378
Stability:
Air Sensitive
InChIKey
RWIVICVCHVMHMU-UHFFFAOYSA-N
CAS DataBase Reference
2038-03-1(CAS DataBase Reference)
NIST Chemistry Reference
4-Morpholineethanamine(2038-03-1)
EPA Substance Registry System
4-Morpholineethanamine (2038-03-1)
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Safety Information

Hazard Codes 
C,T
Risk Statements 
22-34-43-24-40-23/24/25
Safety Statements 
26-36/37/39-45-22
RIDADR 
UN 2735 8/PG 2
WGK Germany 
2
RTECS 
QD7350000
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
Toxicity
guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.

MSDS

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4-(2-Aminoethyl)morpholine Usage And Synthesis

Chemical Properties

clear colorless to pale yellow liq. after melting

Uses

4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II).

Uses

4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:

  • Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.
  • Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.
  • Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.
  • It is also used as a precursor to synthesize a variety of antimicrobial agents.

Definition

ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008

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