ETHYL ISOCYANIDE Chemical Properties

Boiling point:

96.85°C (estimate)

Density 

0.7378

refractive index 

1.3607

Water Solubility 

999mg/L(temperature not stated)

EPA Substance Registry System

Ethane, isocyano- (624-79-3)

ETHYL ISOCYANIDE Usage And Synthesis

Uses

Principal use in toxicology was in the characterization of cytochrome P450 isozymes. Ethyl isocyanide and the reduced cytochrome form a characteristic optical difference spectrum with two peaks in the Soret Region (type III). The pH equilibrium point (the pH at which the two peaks are of equal height) varies between different isozymes.

Preparation

CAUTION: The reaction and distillation should be conducted behind a safety shield. Precautions for handling toxic cyanides should be observed.
To a three-necked flask equipped with a condenser and ground glass stirrer (or Hershberg stirrer) is added 116 gm (0.75 mole) of ethyl iodide and 100 gm (0.75 mole) of silver cyanide. The mixture is refluxed for 2 hr, the stirrer blade raised, the mixture cooled, filtered (see Note a), the solid washed with ether, dried, and 260 gm of a 50% solution of potassium cyanide (2.0 moles) added. The reaction mixture is distilled to afford a mixture of isonitrile and water (see Note b). The crude isonitrile 49.5- 52.3 gm (90-95%) is separated after being salted out of the water. The isonitrile is washed twice with 24-ml portions of ice-cold saturated sodium chloride solution, dried over magnesium sulfate, and fractionally distilled, to afford 25.9-30.3 gm (47-55%), b.p. 77-79°C (760 mm Hg).

ETHYL ISOCYANIDE(624-79-3)Related Product Information

• Benzyl isocyanide
• N-BUTYLISOCYANIDE
• I-PROPYLISOCYANIDE
• 3-Isocyanatopropyltrimethoxysilane
• T-BUTYL ISOCYANOACETATE
• TERT-BUTYL ISOCYANIDE
• 1,6-DIISOCYANOHEXANE
• CYCLOHEXYL ISOCYANIDE
• 2-Morpholinoethyl isocyanide
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• Ethyl isocyanoacetate
• METHYL ISOCYANOACETATE
• aerocyanidin
• ISOCYANOMETHYL RESIN
• TRIPHENYLMETHYLISOCYANIDE
• HEXYL ISOCYANIDE
• 6-Oxabicyclo(3.1.0)hex-3-ene-2-methanol, 2-hydroxy-4-isocyano-alpha-me thyl-, (1-alpha,2-beta,2(R*),5-alpha)-(-)-
• XANTHOASCIN