Methyl 5-fluoro-2-methylbenzoate Chemical Properties

Boiling point:

90-92°C 15mm

Density 

1.137±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

liquid

color 

Brown

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

Hazard Note 

Irritant

HS Code 

2916399090

Methyl 5-fluoro-2-methylbenzoate Usage And Synthesis

Uses

Methyl 5-fluoro-2-methylbenzoate was used for the preparation of derivatives of piperidinedione.

Synthesis

5-Fluoro-2-methylbenzoic acid (2.3 g) was dissolved in tetrahydrofuran (THF, 50 ml). To the solution, iodomethane (0.95 ml) and N,N-diisopropylethylamine (3.2 ml) were added sequentially. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was filtered and the filtrate concentrated to give methyl 5-fluoro-2-methylbenzoate (2.3 g; 90% yield).1H-NMR (CDCl3) δ: 2.6 (s, 3H), 3.9 (s, 3H), 7.0-7.2 (m, 2H), 7.6-7.7 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5286 - 5289
[2] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 83-84

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