5-Fluoro-2-methoxyphenol Chemical Properties

Boiling point:

223°C

Density 

1.224

Flash point:

111°C

storage temp. 

2-8°C

form 

liquid

pka

8.97±0.10(Predicted)

color 

Clear

InChI

InChI=1S/C7H7FO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,1H3

InChIKey

PPJKLEQAFZWIQY-UHFFFAOYSA-N

SMILES

C1(O)=CC(F)=CC=C1OC

CAS DataBase Reference

72955-97-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

WGK 3

Hazard Note 

Irritant

HS Code 

2909500090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

5-Fluoro-2-methoxyphenol Usage And Synthesis

Application

5-Fluoro-2-methoxyphenol is an important pesticide and pharmaceutical intermediate. It can be synthesized from methyl ether using butyllithium and trimethoxyboron in the presence of butyllithium and trimethoxyboron. It is used to synthesize alicylates, a drug for treating hypertension.

Synthesis

In a 500 mL four-necked flask add 150 g (0.9 mol) acetyl guaiacol, glacial acetic acid 240 mL, iodine 2.5 g (0.01 mol) at 25 ?? C, stirring dropwise addition of liquid bromine 160 g (2 mol), dropwise addition is complete, heated to 100 ?? C reaction for 10 h, the reaction mixture was cooled to room temperature, with 3000 mL of ethyl acetate was extracted twice, combined with ethyl acetate layer; washed with 500 mL saturated sodium sulfite, then washed with 500 mL saturated saline, recovery of ethyl acetate to obtain the crude product, light yellow colloidal 180.0 g, light yellow colloidal material. The reaction mixture was cooled to room temperature, extracted with 3000 mL of ethyl acetate twice, combined with the ethyl acetate layer, washed with 500 mL of saturated sodium sulfite, then washed with 500 mL of saturated saline, recovered ethyl acetate to obtain the crude product, light yellow colloidal 180.0 g, purity 98.3%, yield 80.2%.

5-Fluoro-2-methoxyphenol(72955-97-6)Related Product Information

• (Trifluoromethoxy)benzene
• 3-Trifluoromethylphenol
• Guaiacol
• 4-Methoxyphenol
• p-(2-Methoxyethyl) phenol
• 2-Fluorophenol
• 4-Fluorophenol
• 4-(Trifluoromethoxy)aniline
• Methyl 5-fluoro-2-methyl-3-nitrobenzoate
• METHYL 2-METHYL-5-FLUOROBENZOATE
• 5-Fluoro-2-methylbenzoic acid
• 5-FLUORO-2-METHOXYBENZONITRILE
• 5-Fluoro-2-methoxyphenyl acetic acid
• 5-FLUORO-2-METHOXYACETOPHENONE
• 5-FLUORO-2-METHOXYBENZALDEHYDE
• 4-FLUORO-2-METHOXYPHENOL,4-Fluoro-2-methoxyphenol 98%,4-Fluoro-2-methoxyphenol98%
• 2,6-DIFLUORO-3-METHOXYPHENOL
• Fluorine