1,3,5-Trimethoxybenzene Chemical Properties

Melting point:

50-53 °C (lit.)

Boiling point:

255 °C (lit.)

Density 

1,126g/cm

refractive index 

1,533

Flash point:

186 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

methanol: 0.1 g/mL, clear, colorless

form 

Crystalline Powder

color 

White to cream

Water Solubility 

insoluble

BRN 

1307993

InChIKey

LKUDPHPHKOZXCD-UHFFFAOYSA-N

LogP

1.605 (est)

CAS DataBase Reference

621-23-8(CAS DataBase Reference)

NIST Chemistry Reference

1,3,5-Trimethoxybenzene(621-23-8)

EPA Substance Registry System

1,3,5-Trimethoxybenzene (621-23-8)

Safety Information

Hazard Codes 

Xn,F

Risk Statements 

22-20/21/22

Safety Statements 

24/25-36-26

RIDADR 

1325

WGK Germany 

3

RTECS 

DC2810000

Hazard Note 

Flammable Solid/Harmful

TSCA 

Yes

HazardClass 

4.1

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:1,3,5-Trimethoxybenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,3,5-Trimethoxybenzene Usage And Synthesis

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

1,3,5-Trimethoxybenzene(621-23-8)Related Product Information

• Anisole
• Ethylbenzene
• PETROLEUM ETHER
• o-Anisaldehyde
• Trimethyl phosphite
• 3,4,5-Trimethoxyphenol
• (3-Methoxyphenyl)acetonitrile
• 4-Methoxyphenylacetic acid
• 2-Butoxyethanol
• m-Anisyl alcohol
• (Trifluoromethoxy)benzene
• Phloroglucinol
• p-Anisaldehyde
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• Trimethyl borate
• 3,4,5-Trimethoxy benzoic acid
• Dimethyl ether
• Trimethylphloroglucinol