HOMOBUTEIN Chemical Properties

Melting point:

207-212°C

Boiling point:

523.8±50.0 °C(Predicted)

Density 

1.369±0.06 g/cm3(Predicted)

pka

7.43±0.35(Predicted)

form 

Solid

color 

Light yellow to yellow

LogP

2.880 (est)

HOMOBUTEIN Usage And Synthesis

Uses

Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

Definition

ChEBI: Homobutein is a member of chalcones.

IC 50

Toxoplasma

References

[1] Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. DOI:10.3892/or.2012.1870
[2] Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383. PMID:31543702
[3] Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32. DOI:10.1016/j.phytochem.2004.08.050
[4] Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.

HOMOBUTEIN(34000-39-0)Related Product Information

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• 3,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE
• CHRYSOERIOL
• 3',4',5,7-TETRAMETHOXYFLAVONE
• 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
• 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE
• 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
• 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE
• QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER
• 3',4',5',5,7-PENTAMETHOXYFLAVONE
• HOMOBUTEIN
• 3,5,7-TRIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE
• Chalcone
• 4'-METHYLCHRYSOERIOL
• SINENSETIN
• 3,7-DIHYDROXY-3',4'-DIMETHOXYFLAVONE