Chalcone Chemical Properties

Melting point:

55-59 °C

Boiling point:

208 °C25 mm Hg(lit.)

Density 

d462 1.0712

refractive index 

nD62 1.6458

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

dioxane: soluble1g/10 mL, clear, colorless

form 

Granular Powder

color 

Yellow

Merck 

14,2037

BRN 

1210466

LogP

3.080

CAS DataBase Reference

94-41-7(CAS DataBase Reference)

EPA Substance Registry System

2-Propen-1-one, 1,3-diphenyl- (94-41-7)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37

Safety Statements 

22-36/37/39-45

WGK Germany 

3

RTECS 

UD5576750

HS Code 

29143900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Chalcone Usage And Synthesis

Description

Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.

Chemical Properties

light yellow powder

Uses

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Uses

Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.

Definition

ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.

Preparation

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).

Biological Activity

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Safety Profile

Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]

Chalcone(94-41-7)Related Product Information

• 2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE
• 2',3,4,4'-Tetrahydroxy-trans-chalcone
• trans-Chalcone
• Styrene
• 4-Chloro-4'-methoxy-trans-chalcone
• (E)-2',4-Dihydroxy-4'-(β-D-glucopyranosyloxy)chalcone
• (E)-4'-(Dimethylamino)chalcone
• 4-Diethylamino-α-methyl-3',4',5'-trimethoxy-trans-chalcone
• 4-Amino-β-methyl-3',4',5'-trimethoxy-trans-chalcone
• α-Methyl-2',3',4'-trimethoxy-trans-chalcone
• 4-Acetylamino-3',4',5'-trimethoxy-trans-chalcone
• 4-Nitro-cis-chalcone
• 2'-HYDROXY-6'-METHYL-3,4-METHYLENEDIOXY CHALCONE
• 4-Butoxy-3',4',5'-trimethoxy-trans-chalcone
• 3-Dimethylamino-3',4',5'-trimethoxy-trans-chalcone
• 3,4'-Dinitro-trans-chalcone
• 4-Diethylamino-α-methyl-2',3',4'-trimethoxy-trans-chalcone
• 4-Nitro-3',4',5'-trimethoxy-trans-chalcone