2-Isopropyl-4-(methylaminomethyl)thiazole Chemical Properties

Boiling point:

230.9±15.0 °C(Predicted)

Density 

1.039±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

pka

8.06±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

InChI

InChI=1S/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3

InChIKey

HWSFABGWAXURNG-UHFFFAOYSA-N

SMILES

S1C=C(CNC)N=C1C(C)C

CAS DataBase Reference

154212-60-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

21/22-38-41-51/53

Safety Statements 

26-36/37/39-61

HS Code 

2934100090

2-Isopropyl-4-(methylaminomethyl)thiazole Usage And Synthesis

Synthesis

To a 250 mL three-necked flask was added 4-(chloromethyl)-2-isopropylthiazole (9 g, 0.05 mol) and 40% aqueous methylamine solution (100 mL). The reaction mixture was heated to 50-60 °C and the reaction was stirred at this temperature overnight. After the reaction was completed, the mixture was cooled to room temperature. Dichloromethane (100 mL) and isopropanol (30 mL) were added to the reaction mixture, which was stirred thoroughly and left to stratify. The aqueous phase was separated and the aqueous phase was extracted with dichloromethane 3 times. All organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (silica gel, appropriate eluent) to afford 2-isopropyl-4-(methylaminomethyl)thiazole (6.5 g, 74% yield) as a colorless liquid.

References

[1] Patent: CN104557763, 2017, B. Location in patent: Paragraph 0026; 0034; 0035; 0036; 0046; 0056; 0064-0066
[2] Patent: WO2006/90270, 2006, A1. Location in patent: Page/Page column 8-9

2-Isopropyl-4-(methylaminomethyl)thiazole(154212-60-9)Related Product Information

• METSULFURON METHYL
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• Bensulfuron methyl
• Methyl salicylate
• 2-Aminothiazole-4-acetic acid
• 4-Methylthiazole
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• ISOPROPYL LAURATE
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• Methyl acetate
• Kresoxim-methyl
• Isopropyl alcohol
• 5-Amino-2-methylpyridine
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• Tris(hydroxymethyl)aminomethane
• THIAZOLE ORANGE