N-Acetyl-L-proline
N-Acetyl-L-proline Basic information
- Product Name:
- N-Acetyl-L-proline
- Synonyms:
-
- N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline
- (2S)-1-acetyl-2-pyrrolidinecarboxylate
- (S)-N-Acetylproline
- L-N-Acetylproline
- NSC 280718
- N-Ac-Pro-OH
- ASINEX-REAG BAS 16579166
- ACETYL-L-PROLINE
- CAS:
- 68-95-1
- MF:
- C7H11NO3
- MW:
- 157.17
- EINECS:
- 200-698-9
- Product Categories:
-
- A - H
- Amino Acids
- chiral
- Amino Acid Derivatives
- Amino Acids
- Modified Amino Acids
- ACETYLGROUP
- PYRROLE
- pharmacetical
- N-Acetyl-Amino acid series
- amino
- bc0001
- Mol File:
- 68-95-1.mol
N-Acetyl-L-proline Chemical Properties
- Melting point:
- 115-117 °C
- alpha
- -86 º (c=1 EtOH)
- Boiling point:
- 366.2±35.0 °C(Predicted)
- Density
- 1.274±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 3.69±0.20(Predicted)
- form
- Powder
- color
- White to off-white
- BRN
- 83200
- InChI
- InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
- InChIKey
- GNMSLDIYJOSUSW-LURJTMIESA-N
- SMILES
- C(O)(=O)[C@@H]1CCCN1C(C)=O
- CAS DataBase Reference
- 68-95-1(CAS DataBase Reference)
- NIST Chemistry Reference
- L-proline, 1-acetyl-(68-95-1)
MSDS
- Language:English Provider:N-Acetyl-L-proline
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
N-Acetyl-L-proline Usage And Synthesis
Chemical Properties
white to off-white powder
Uses
N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.
Definition
ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.
Biochem/physiol Actions
N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.
References
[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.
Description
N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However, these methods may result in the production of many byproducts[1].
N-Acetyl-L-prolineSupplier
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- 15061806929; 15061806929
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- 021-61998208 18217752821
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- 022-83946278 13820503911
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- market03@meryer.com
N-Acetyl-L-proline(68-95-1)Related Product Information
- N-Acetyl-L-cysteine
- L-Proline
- cis-4-Hydroxy-L-proline
- Acetylacetone
- Acetyl chloride
- D-Proline
- L-PROLINE-(4-3H(N))
- N-Acetyl-L-valine
- AC-TYR-NH2
- N-ALPHA-ACETYL-D-PROLINE,N-ACETYL-D-PROLINE,ACETYL-D-PROLINE
- Fosinopril sodium
- 4β-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline,(4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline Disodium Salt
- Fosinopril
- N-ALPHA-ACETYL-L-PROLINE AMIDE,ACETYL-L-PROLINE AMIDE
- N6-Trifluoroacetyl-L-lysyl-L-proline
- 1-ACETYLPYRROLIDINE
- 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-proline tert-Butyl Ester,7-Methoxycoumarin-4-Acetyl-L-proline tert-Butyl Ester
- (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenyl-d5-butyl)phosphinyl]acetyl]-L-proline Sodium Salt