H-ASP(OTBU)-OTBU HCL Chemical Properties

Melting point:

152-155 °C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

soluble in Methanol

form 

Solid

color 

White to Almost white

optical activity

10.6596°(C=1.0045g/100ml ETOH)

BRN 

5652807

InChIKey

GVLZIMQSYQDAHB-QRPNPIFTSA-N

CAS DataBase Reference

1791-13-5

Safety Information

WGK Germany 

3

F 

10-21

HS Code 

29224999

MSDS

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H-ASP(OTBU)-OTBU HCL Usage And Synthesis

Chemical Properties

White powder

Uses

L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester.

Biochem/physiol Actions

L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester (G7501).

Synthesis

General procedure for the synthesis of di-tert-butyl (S)-2-aminosuccinate hydrochloride from Cbz-Asp(OtBu)-OtBu 18: Pd/C (10%, 830 mg, 10% w/w) was added to an ethanol solution of Cbz-Asp(OtBu)-OtBu 18 (8.25 g, 21.8 mmol) and ammonium formate (34.3 g, 0.54 mol). ) in an ethanol solution (20 mL). The suspension was stirred overnight at room temperature. Upon completion of the reaction, the suspension was filtered through diatomaceous earth and the solvent was removed under reduced pressure. The resulting residue was dissolved in ethyl acetate and the solution was cooled to 0°C. Subsequently, an ethyl acetate solution saturated with HCl was added dropwise and stirred for 15 minutes. The precipitated solid was filtered, washed with cold ethyl acetate and dried under vacuum to afford NH2-Asp(OtBu)-OtBu hydrochloride 16 (4.28 g, 17.4 mmol, 80% yield) as a white solid, which can be used in subsequent reactions without further purification.

References

[1] Tetrahedron, 2014, vol. 70, # 44, p. 8343 - 8347

H-ASP(OTBU)-OTBU HCL(1791-13-5)Related Product Information

• Dimethyl L-aspartate hydrochloride
• beta-Methyl L-aspartate hydrochloride
• L-Aspartic acid 1-tert-butyl 4-Methyl
• H-ASP(OTBU)-OME HCL
• 4-Methyl hydrogen L-aspartate
• H-ASP(OET)-OET HCL
• H-Asp(OMPe)-OH
• L-Aspartic acid 4-cyclohexyl ester
• H-ASP-OTBU
• 3-Isopropoxypropylamine
• Glycine ethyl ester hydrochloride
• Methyl 3-aminopropionate hydrochloride
• H-ASP(OTBU)-OTBU HCL
• H-BETA-ALA-OTBU HCL
• Ethyl 3-aminopropanoate hydrochloride
• L-Ala-OtBU.HCl
• TERT-BUTYL (3R)-3-AMINOBUTANOATE
• Glycine tert butyl ester hydrochloride