CNQX Chemical Properties

Melting point:

300 °C

Boiling point:

374.31°C (rough estimate)

Density 

1.5507 (rough estimate)

refractive index 

1.6590 (estimate)

RTECS 

VD1520000

storage temp. 

protect from light

solubility 

H₂O: 10 mg/mL

form 

solid

pka

8.16±0.20(Predicted)

color 

orange to red

Stability:

Store Tightly Sealed at RT

CAS DataBase Reference

115066-14-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

CNQX Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

CNQX disodium salt hydrate has been used as:

• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Uses

A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively

Uses

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

Definition

ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative.

Biological Activity

Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

storage

Room temperature

CNQX(115066-14-3)Related Product Information

• 2-Nitrobenzonitrile
• N,N'-Dimethyloxalamide
• 2-HYDROXY-6-METHYLQUINOXALINE
• 3-Methyl-4-nitroaniline
• 1,2,3,4-TETRAHYDRO-QUINOXALINE
• 4-ACETAMIDOBENZONITRILE
• 2,3-DIHYDROXYQUINOXALINE
• 3,4-Diaminobenzonitrile
• 4-ACETAMIDO-2-METHYLNITROBENZENE
• 6-NITROQUINOXALINE-2,3-DIONE
• 2,5-Diaminobenzonitrile
• 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE
• 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE
• 4-(N-Methylamino)benzonitrile
• CNQX
• N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2)
• PYRAZINE-2,3-DIOL
• N-(4-amino-3-methylphenyl)acetamide