3-Methyl-4-nitroaniline Chemical Properties

Melting point:

136-137°C

Boiling point:

330.0±22.0 °C(Predicted)

Density 

1.269±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Methanol

form 

Solid

pka

1.12±0.10(Predicted)

color 

Brown Crystalline

BRN 

2209112

CAS DataBase Reference

611-05-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-33-51/53

Safety Statements 

28-36/37-45-61

RIDADR 

2660

HazardClass 

6.1

PackingGroup 

III

HS Code 

2921420090

MSDS

• Language:English Provider:3-Amino-6-nitrotoluene
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3-Methyl-4-nitroaniline Usage And Synthesis

Chemical Properties

Brown Crystalline Solid

Uses

3-Methyl-4-nitrobenzeneamine (cas# 611-05-2) is a compound useful in organic synthesis.

Synthesis Reference(s)

Synthetic Communications, 18, p. 2161, 1988 DOI: 10.1080/00397918808068287

Synthesis

General procedure for the synthesis of 3-methyl-4-nitroaniline (20-2) from 3-methyl-4-nitrobenzamide (20-1, 40 g, 222 mmol): 20-1 was dissolved in 400 mL of methanol/water (v/v=1/1) mixed solvent and cooled to 0 °C. Subsequently, sodium hydroxide (35.6 g, 888 mmol) was added to the solution and stirred for 0.5 hours. Sodium hypochlorite solution (380 g, 556 mmol) was added slowly and dropwise at 0°C. The reaction mixture was gradually warmed up to room temperature (20°C) and stirring was continued for 18 hours. After that, the mixture was further warmed up to 35°C and stirred for 1 hour, then warmed up to 75°C and stirred for 0.5 hours. After completion of the reaction, the mixture was cooled to room temperature. The pH was adjusted to 6.0 with hydrochloric acid, at which time a brown precipitate was produced. The precipitate was collected by filtration and washed twice with 200 mL of water to give the final 20-2 (29 g, 86% yield) as a tan powder.

References

[1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 297

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