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m-Toluidine

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m-Toluidine Basic information

Product Name:
m-Toluidine
Synonyms:
  • M-Toluidine, 99% 5ML
  • M-TOLUIDINE FOR SYNTHESIS 100 ML
  • M-TOLUIDINE FOR SYNTHESIS 1 L
  • Between toluidine
  • M-Toluidine 0
  • AKOS BBS-00003559
  • 3-METHYLALANINE
  • 3-METHYLANILINE
CAS:
108-44-1
MF:
C7H9N
MW:
107.15
EINECS:
203-583-1
Product Categories:
  • amine
  • Intermediates of Dyes and Pigments
  • 3-Amino-1-Methylbenzene
  • Azo dye
  • Organics
Mol File:
108-44-1.mol
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m-Toluidine Chemical Properties

Melting point:
-30 °C
Boiling point:
203-204 °C(lit.)
Density 
0.999 g/mL at 25 °C(lit.)
vapor pressure 
0.3 hPa (20 °C)
refractive index 
n20/D 1.567(lit.)
Flash point:
186 °F
storage temp. 
Store below +30°C.
solubility 
0.2 g/100 mL (20°C)
pka
4.73(at 25℃)
form 
Crystalline Solid or Liquid
color 
White
PH
7 (H2O, 20℃)
Water Solubility 
0.2 g/100 mL (20 ºC)
Merck 
14,9536
BRN 
635944
Exposure limits
TLV-TWA skin 2-ppm (~9 mg/m3) (ACGIH).
InChIKey
JJYPMNFTHPTTDI-UHFFFAOYSA-N
CAS DataBase Reference
108-44-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3-methyl-(108-44-1)
EPA Substance Registry System
m-Toluidine (108-44-1)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
45-23/24/25-33-50
Safety Statements 
53-28-36/37-45-61-28A
RIDADR 
UN 1708 6.1/PG 2
WGK Germany 
2
RTECS 
XU2800000
8-23
Autoignition Temperature
>500 °C
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29171990
HS Code 
29214300
Hazardous Substances Data
108-44-1(Hazardous Substances Data)

MSDS

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m-Toluidine Usage And Synthesis

Chemical Properties

Colorless liquid. Slightly soluble in water; soluble in alcohol or ether. Combustible.

Uses

Dyes, manufacture of organic chemicals.

Uses

m-Toluidine is an intermediate in the manu facture of dyes and other chemicals.

Synthesis Reference(s)

Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749

General Description

A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.

Reactivity Profile

m-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

The toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.

Safety Profile

Poison by ingestion and intraperitoneal routes, A skin and eye irritant. Flammable when exposed to heat or flame. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx. See also ANILINE and o-TOLUIDINE.

Carcinogenicity

In an 18-month carcinogenicity diet evaluation in maleCD rats (8000 ppm for 3 months, and then 4000 ppm for additional 15 months; or 16,000 ppm for 3 months, and then 8000 for additional 15 months), and male and female CD-1 mice (16,000 ppm for 5 months, and then 4000 ppm in males and 8000 ppm in females for additional 13 months; or 32,000 ppm in both sexes for 5 months, and then 8000 ppm in males and 16,000 ppm in females for additional 13 months), there was no evidence of a significant increase of incidence of any kind of tumor in the rats, and only a significant increase in liver tumors in male mice.

Purification Methods

It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]

m-ToluidineSupplier

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